Applications of MDMA in Modern Medicine - A Literature Review
MDMA or 3,4- methylenedioxymethamphetamine is a psychoactive substance, exhibiting mild hallucinogenic properties, that became widely known as a recreational party drug. However, its ability in helping individuals access deeply rooted emotions has prompted significant interest in its potential appli...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56620 |
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| author | Wiktoria Podlasiewicz Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Tomaszewska Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska |
| author_facet | Wiktoria Podlasiewicz Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Tomaszewska Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska |
| author_sort | Wiktoria Podlasiewicz |
| collection | DOAJ |
| description | MDMA or 3,4- methylenedioxymethamphetamine is a psychoactive substance, exhibiting mild hallucinogenic properties, that became widely known as a recreational party drug. However, its ability in helping individuals access deeply rooted emotions has prompted significant interest in its potential applications within clinical practice. MDMA’s mechanism of action involves increasing the release of serotonin, dopamine and oxytocin. This process enhances neuroplasticity, fosters empathy and aids in trauma processing and fear extinction. This study aims to explore the potential uses of MDMA in medicine, particularly in treating mental illnesses. The article was developed using data from the „PubMed” and „Google Scholar” databases, with particular emphasis on articles published after 2021. When combined with psychotherapy, MDMA offers significant therapeutic benefits, especially for patients resistant to conventional treatments. Existing research primarily highlights its effectiveness in managing post traumatic stress disorder (PTSD) and anxiety disorders, with emerging evidence suggesting potential benefits for conditions like depression and eating disorder. While recreational use of MDMA poses risks, its use in a controlled environment demonstrates a favourable safety profile. Despite the highly promising results of MDMA- assisted therapy so far, additional clinical research is crucial to enable this drug to revolutionise future treatment methods.
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| format | Article |
| id | doaj-art-ec58390f28c9438db1d824dfa227464f |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-ec58390f28c9438db1d824dfa227464f2025-01-15T08:16:49ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56620Applications of MDMA in Modern Medicine - A Literature ReviewWiktoria Podlasiewicz0https://orcid.org/0009-0001-6578-5297Paweł Siudziński1https://orcid.org/0009-0002-4476-9412Mateusz Łyko2https://orcid.org/0009-0009-2530-2789Alicja Skoczylas3https://orcid.org/0009-0002-2185-5406Jakub Kurasz4https://orcid.org/0009-0004-3955-1552Wojciech Maj5https://orcid.org/0009-0003-2869-3718Wiktoria Tomaszewska6https://orcid.org/0009-0005-6166-1659Katarzyna Pala7https://orcid.org/0009-0004-0787-3872Piotr Dudziak8https://orcid.org/0009-0000-6173-740XAnna Nowak9https://orcid.org/0009-0005-8833-1107Maria Golińska10https://orcid.org/0009-0008-2772-6131Wroclaw Medical UniversityUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiMDMA or 3,4- methylenedioxymethamphetamine is a psychoactive substance, exhibiting mild hallucinogenic properties, that became widely known as a recreational party drug. However, its ability in helping individuals access deeply rooted emotions has prompted significant interest in its potential applications within clinical practice. MDMA’s mechanism of action involves increasing the release of serotonin, dopamine and oxytocin. This process enhances neuroplasticity, fosters empathy and aids in trauma processing and fear extinction. This study aims to explore the potential uses of MDMA in medicine, particularly in treating mental illnesses. The article was developed using data from the „PubMed” and „Google Scholar” databases, with particular emphasis on articles published after 2021. When combined with psychotherapy, MDMA offers significant therapeutic benefits, especially for patients resistant to conventional treatments. Existing research primarily highlights its effectiveness in managing post traumatic stress disorder (PTSD) and anxiety disorders, with emerging evidence suggesting potential benefits for conditions like depression and eating disorder. While recreational use of MDMA poses risks, its use in a controlled environment demonstrates a favourable safety profile. Despite the highly promising results of MDMA- assisted therapy so far, additional clinical research is crucial to enable this drug to revolutionise future treatment methods. https://apcz.umk.pl/JEHS/article/view/56620MDMApsychiatrypsychotherapyneurobiologyserotonin |
| spellingShingle | Wiktoria Podlasiewicz Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Tomaszewska Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska Applications of MDMA in Modern Medicine - A Literature Review Journal of Education, Health and Sport MDMA psychiatry psychotherapy neurobiology serotonin |
| title | Applications of MDMA in Modern Medicine - A Literature Review |
| title_full | Applications of MDMA in Modern Medicine - A Literature Review |
| title_fullStr | Applications of MDMA in Modern Medicine - A Literature Review |
| title_full_unstemmed | Applications of MDMA in Modern Medicine - A Literature Review |
| title_short | Applications of MDMA in Modern Medicine - A Literature Review |
| title_sort | applications of mdma in modern medicine a literature review |
| topic | MDMA psychiatry psychotherapy neurobiology serotonin |
| url | https://apcz.umk.pl/JEHS/article/view/56620 |
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