The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway

The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway

Abstract Background Thyroid-associated ophthalmopathy (TAO) is a thyroid function-related, organ-specific autoimmune disease that primarily leads to specific reactive changes and tissue remodeling in the periocular region. The exact pathogenesis of TAO remains unclear. Methods High-throughput gene e...

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Main Authors: Xuemei Li, Siyi Wang, Hanwen Cao, Simin Xu, Chao Xiong, Jinhai Yu, Yunxiu Chen, Zhangjun Ren, Min Li, Ying Hu, Puying Gan, Qihua Xu, Yaohua Wang, Hongfei Liao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-025-06443-0
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