A mode of action protein based approach that characterizes the relationships among most major diseases

Abstract Disease classification is important for understanding disease commonalities on both the phenotypical and molecular levels. Based on predicted disease mode of action (MOA) proteins, our algorithm PICMOA (Pan-disease Classification in Mode of Action Protein Space) classifies 3526 diseases acr...

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Bibliographic Details
Main Authors: Hongyi Zhou, Brice Edelman, Jeffrey Skolnick
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-93377-8
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