LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS
Lipid droplets (LDs) are present in the nucleus, though much less abundant than cytoplasmic LDs. We investigated nuclear LDs generated in amino acid-deprived conditions, and found that diacylglycerol (DAG), produced by ATGL-mediated hydrolysis of triacylglycerol (TAG) in cytoplasmic LDs, flows into...
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| Language: | English |
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PAGEPress Publications
2025-08-01
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| Series: | European Journal of Histochemistry |
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| Online Access: | https://www.ejh.it/ejh/article/view/4300 |
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Lipid droplets (LDs) are present in the nucleus, though much less abundant than cytoplasmic LDs. We investigated nuclear LDs generated in amino acid-deprived conditions, and found that diacylglycerol (DAG), produced by ATGL-mediated hydrolysis of triacylglycerol (TAG) in cytoplasmic LDs, flows into the inner nuclear membrane (INM) and gives rise to nuclear LDs. DAG in the INM is trafficked to PML nuclear bodies (PML NBs) via small vesicles, whose formation is abolished in PML knockout cells. These findings uncover a new class of vesicles in the nucleus that link PML NBs to TAG metabolism and prompt reconsideration of our understanding of the PML NB architecture.
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| format | Article |
| id | doaj-art-ec4a304700c047c2b3503ba147167eec |
| institution | Kabale University |
| issn | 1121-760X 2038-8306 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj-art-ec4a304700c047c2b3503ba147167eec2025-08-23T11:19:34ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062025-08-0169s210.4081/ejh.2025.4300LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS Lipid droplets (LDs) are present in the nucleus, though much less abundant than cytoplasmic LDs. We investigated nuclear LDs generated in amino acid-deprived conditions, and found that diacylglycerol (DAG), produced by ATGL-mediated hydrolysis of triacylglycerol (TAG) in cytoplasmic LDs, flows into the inner nuclear membrane (INM) and gives rise to nuclear LDs. DAG in the INM is trafficked to PML nuclear bodies (PML NBs) via small vesicles, whose formation is abolished in PML knockout cells. These findings uncover a new class of vesicles in the nucleus that link PML NBs to TAG metabolism and prompt reconsideration of our understanding of the PML NB architecture. https://www.ejh.it/ejh/article/view/4300HISTOCHEMISTRY OF THE NUCLEUS |
| spellingShingle | LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS European Journal of Histochemistry HISTOCHEMISTRY OF THE NUCLEUS |
| title | LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS |
| title_full | LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS |
| title_fullStr | LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS |
| title_full_unstemmed | LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS |
| title_short | LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS |
| title_sort | lipid droplets and nuclear lipid dynamics |
| topic | HISTOCHEMISTRY OF THE NUCLEUS |
| url | https://www.ejh.it/ejh/article/view/4300 |