Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process
Background. We sought to develop diagnostic test guidance definitions for pediatric enteric infections to facilitate the interpretation of positive test results in the era of multianalyte molecular diagnostic test platforms. Methods. We employed a systematic, two-phase, modified Delphi consensus pro...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2018/2589826 |
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| author | Antonia S. Stang Melanie Trudeau Otto G. Vanderkooi Bonita E. Lee Linda Chui Xiao-Li Pang Vanessa Allen Carey-Ann D. Burnham David M. Goldfarb Judy MacDonald Brendon Parsons Astrid Petrich Frank Pollari Phillip I. Tarr Graham Tipples Ran Zhuo Stephen B. Freedman |
| author_facet | Antonia S. Stang Melanie Trudeau Otto G. Vanderkooi Bonita E. Lee Linda Chui Xiao-Li Pang Vanessa Allen Carey-Ann D. Burnham David M. Goldfarb Judy MacDonald Brendon Parsons Astrid Petrich Frank Pollari Phillip I. Tarr Graham Tipples Ran Zhuo Stephen B. Freedman |
| author_sort | Antonia S. Stang |
| collection | DOAJ |
| description | Background. We sought to develop diagnostic test guidance definitions for pediatric enteric infections to facilitate the interpretation of positive test results in the era of multianalyte molecular diagnostic test platforms. Methods. We employed a systematic, two-phase, modified Delphi consensus process consisting of three web-based surveys and an expert panel face-to-face meeting. In phase 1, we surveyed an advisory panel of North American experts to select pathogens requiring diagnostic test guidance definition development. In phase 2, we convened a 14-member expert panel to develop, refine, and select the final definitions through two web-based questionnaires interspersed with a face-to-face meeting. Both questionnaires asked panelists to rate the degree to which they agreed that if the definition is met the pathogen is likely to be causative of clinical illness. Results. The advisory panel survey identified 19 pathogens requiring definitions. In the expert panel premeeting survey, 13 of the 19 definitions evaluated were rated as being highly likely (“agree” or “strongly agree”) to be responsible for acute gastroenteritis symptoms by ≥67% of respondent panel members. The definitions for the remaining six pathogens (Aeromonas, Clostridium difficile, Edwardsiella, nonenteric adenovirus, astrovirus, and Entamoeba histolytica) were indeterminate. After the expert panel meeting, only two of the modified definitions, C. difficile and E. histolytica/dispar, failed to achieve the a priori specified threshold of ≥67% agreement. Conclusions. We developed diagnostic test guidance definitions to assist healthcare providers for 17 enteric pathogens. We identified two pathogens that require further research and definition development. |
| format | Article |
| id | doaj-art-ec4860c8080b48cb9de07823f2e2a682 |
| institution | DOAJ |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-ec4860c8080b48cb9de07823f2e2a6822025-08-20T03:21:24ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932018-01-01201810.1155/2018/25898262589826Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus ProcessAntonia S. Stang0Melanie Trudeau1Otto G. Vanderkooi2Bonita E. Lee3Linda Chui4Xiao-Li Pang5Vanessa Allen6Carey-Ann D. Burnham7David M. Goldfarb8Judy MacDonald9Brendon Parsons10Astrid Petrich11Frank Pollari12Phillip I. Tarr13Graham Tipples14Ran Zhuo15Stephen B. Freedman16Departments of Pediatrics, Emergency Medicine and Community Health Sciences, University of Calgary, Alberta Children’s Hospital Research Institute, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaDepartments of Pediatrics, Microbiology, Immunology and Infectious Diseases, Pathology & Laboratory Medicine and Community Health Sciences, University of Calgary, Alberta Children’s Hospital Research Institute, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, CanadaDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, CanadaDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, CanadaPublic Health Ontario Laboratories, University of Toronto, Toronto, Ontario, CanadaDepartments of Pathology & Immunology, Molecular Microbiology, and Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USADepartment of Pathology and Laboratory Medicine, BC Children’s Hospital, Vancouver, British Columbia, CanadaPopulation, Public and Indigenous Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, CanadaEnterics Surveillance and Population Studies Division, Centre for Food-Borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, CanadaDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USADepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, CanadaDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, CanadaSections of Pediatric Emergency Medicine and Gastroenterology, Departments of Pediatrics, University of Calgary, Alberta Children’s Hospital, Calgary, Alberta, CanadaBackground. We sought to develop diagnostic test guidance definitions for pediatric enteric infections to facilitate the interpretation of positive test results in the era of multianalyte molecular diagnostic test platforms. Methods. We employed a systematic, two-phase, modified Delphi consensus process consisting of three web-based surveys and an expert panel face-to-face meeting. In phase 1, we surveyed an advisory panel of North American experts to select pathogens requiring diagnostic test guidance definition development. In phase 2, we convened a 14-member expert panel to develop, refine, and select the final definitions through two web-based questionnaires interspersed with a face-to-face meeting. Both questionnaires asked panelists to rate the degree to which they agreed that if the definition is met the pathogen is likely to be causative of clinical illness. Results. The advisory panel survey identified 19 pathogens requiring definitions. In the expert panel premeeting survey, 13 of the 19 definitions evaluated were rated as being highly likely (“agree” or “strongly agree”) to be responsible for acute gastroenteritis symptoms by ≥67% of respondent panel members. The definitions for the remaining six pathogens (Aeromonas, Clostridium difficile, Edwardsiella, nonenteric adenovirus, astrovirus, and Entamoeba histolytica) were indeterminate. After the expert panel meeting, only two of the modified definitions, C. difficile and E. histolytica/dispar, failed to achieve the a priori specified threshold of ≥67% agreement. Conclusions. We developed diagnostic test guidance definitions to assist healthcare providers for 17 enteric pathogens. We identified two pathogens that require further research and definition development.http://dx.doi.org/10.1155/2018/2589826 |
| spellingShingle | Antonia S. Stang Melanie Trudeau Otto G. Vanderkooi Bonita E. Lee Linda Chui Xiao-Li Pang Vanessa Allen Carey-Ann D. Burnham David M. Goldfarb Judy MacDonald Brendon Parsons Astrid Petrich Frank Pollari Phillip I. Tarr Graham Tipples Ran Zhuo Stephen B. Freedman Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process |
| title_full | Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process |
| title_fullStr | Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process |
| title_full_unstemmed | Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process |
| title_short | Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process |
| title_sort | diagnostic interpretation guidance for pediatric enteric pathogens a modified delphi consensus process |
| url | http://dx.doi.org/10.1155/2018/2589826 |
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