A clinically feasible algorithm for the parallel detection of glioma‐associated copy number variation markers based on shallow whole genome sequencing

A clinically feasible algorithm for the parallel detection of glioma‐associated copy number variation markers based on shallow whole genome sequencing

Abstract Molecular features are incorporated into the integrated diagnostic system for adult diffuse gliomas. Of these, copy number variation (CNV) markers, including both arm‐level (1p/19q codeletion, +7/−10 signature) and gene‐level (EGFR gene amplification, CDKN2A/B homozygous deletion) changes,...

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Bibliographic Details
Main Authors: Shuai Wu, Chenyu Ma, Jiawei Cai, Chenkang Yang, Xiaojia Liu, Chen Luo, Jingyi Yang, Zhang Xiong, Dandan Cao, Hong Chen
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:The Journal of Pathology: Clinical Research
Subjects:
CNV detection algorithm
shallow whole genome sequencing (sWGS)
glioma diagnoses
clinical practice
Online Access:https://doi.org/10.1002/2056-4538.70005
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