Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension
ABSTRACT The purpose of this case series is to report eight patients with giant prolactinomas emphasizing presentations and a treatment complication. The study group included six men and two women. The median age was 29 years (18–54 years); median serum prolactin level was 4,562 ng/ml (1,543–18,690...
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Thieme Revinter Publicações
2016-07-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000700544&lng=en&tlng=en |
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| author | Marise Ribeiro de Sousa Berriel Giovanna Aparecida Balarini Lima Alessandro Severo Alves de Melo Maria Laura Vasconcelos dos Santos Hassan Rahhal Giselle Fernandes Taboada |
| author_facet | Marise Ribeiro de Sousa Berriel Giovanna Aparecida Balarini Lima Alessandro Severo Alves de Melo Maria Laura Vasconcelos dos Santos Hassan Rahhal Giselle Fernandes Taboada |
| author_sort | Marise Ribeiro de Sousa Berriel |
| collection | DOAJ |
| description | ABSTRACT The purpose of this case series is to report eight patients with giant prolactinomas emphasizing presentations and a treatment complication. The study group included six men and two women. The median age was 29 years (18–54 years); median serum prolactin level was 4,562 ng/ml (1,543–18,690 ng/ml); three patients (37.5%) had panhypopituitarism; median tumor diameter was 50 mm (41–60 mm). Five patients (62.5%) had visual field defects and three had improvement during treatment; six patients (75%) reached prolactin normalization, with a median time of 10.5 months (7–84 months) and median dose of 2.0 mg/week (1.0 to 3.0 mg/week). One patient presented as a true incidentaloma. One patient presented a cerebrospinal fluid leakage during medical treatment and refused surgery, however this resolved with conservative measures. This case series illustrate a rare subtype of macroprolactinomas, the importance of considering unusual presentations at the diagnosis, the effectiveness of pharmacological treatment and its possible complications. |
| format | Article |
| id | doaj-art-ec469e2b58d3483da3b7f3ddb81a8034 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2016-07-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-ec469e2b58d3483da3b7f3ddb81a80342025-08-20T02:21:48ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272016-07-0174754454810.1590/0004-282X20160083S0004-282X2016000700544Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extensionMarise Ribeiro de Sousa BerrielGiovanna Aparecida Balarini LimaAlessandro Severo Alves de MeloMaria Laura Vasconcelos dos SantosHassan RahhalGiselle Fernandes TaboadaABSTRACT The purpose of this case series is to report eight patients with giant prolactinomas emphasizing presentations and a treatment complication. The study group included six men and two women. The median age was 29 years (18–54 years); median serum prolactin level was 4,562 ng/ml (1,543–18,690 ng/ml); three patients (37.5%) had panhypopituitarism; median tumor diameter was 50 mm (41–60 mm). Five patients (62.5%) had visual field defects and three had improvement during treatment; six patients (75%) reached prolactin normalization, with a median time of 10.5 months (7–84 months) and median dose of 2.0 mg/week (1.0 to 3.0 mg/week). One patient presented as a true incidentaloma. One patient presented a cerebrospinal fluid leakage during medical treatment and refused surgery, however this resolved with conservative measures. This case series illustrate a rare subtype of macroprolactinomas, the importance of considering unusual presentations at the diagnosis, the effectiveness of pharmacological treatment and its possible complications.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000700544&lng=en&tlng=enprolactinomaagonistas de dopaminahiperprolactinemia |
| spellingShingle | Marise Ribeiro de Sousa Berriel Giovanna Aparecida Balarini Lima Alessandro Severo Alves de Melo Maria Laura Vasconcelos dos Santos Hassan Rahhal Giselle Fernandes Taboada Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension Arquivos de Neuro-Psiquiatria prolactinoma agonistas de dopamina hiperprolactinemia |
| title | Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension |
| title_full | Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension |
| title_fullStr | Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension |
| title_full_unstemmed | Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension |
| title_short | Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension |
| title_sort | prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension |
| topic | prolactinoma agonistas de dopamina hiperprolactinemia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000700544&lng=en&tlng=en |
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