Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis
ObjectiveTo retrospectively analyze the clinical characteristics and independent risk factors of severe influenza combined with febrile seizures, and to provide more basis for early clinical intervention.MethodsA total of 161 children with severe influenza were collected as study subjects and divide...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1418499/full |
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| author | Peng Li Peng Li Mei Chen Mei Chen Daobin Wang Xue Zhang Ruiyang Sun Wanyu Jia Shuqin Fu Junhao Cui Chunlan Song Chunlan Song |
| author_facet | Peng Li Peng Li Mei Chen Mei Chen Daobin Wang Xue Zhang Ruiyang Sun Wanyu Jia Shuqin Fu Junhao Cui Chunlan Song Chunlan Song |
| author_sort | Peng Li |
| collection | DOAJ |
| description | ObjectiveTo retrospectively analyze the clinical characteristics and independent risk factors of severe influenza combined with febrile seizures, and to provide more basis for early clinical intervention.MethodsA total of 161 children with severe influenza were collected as study subjects and divided into convulsive (FC) group (40 cases) and non-convulsive (NFC) group (121 cases) according to whether they had febrile seizures. The demographic characteristics and clinical data of the two groups were analyzed. Multivariate logistic regression was used to analyze the risk factors of severe influenza combined with febrile seizures. The predictive efficacy was evaluated by receiver operating characteristic (ROC) curve analysis.Results(1) Multiple logistic regression analysis revealed that C-reactive protein (CRP) levels, Serum interleukin 6 (IL-6) levels, Days from onset of Flu symptoms to hospitalization, cerebrospinal fluid protein (CSF-TP) levels and the influenza virus type A (FluA) infection rate were found to be independent risk factors for severe influenza combined with febrile seizures in children. (2) ROC curve analysis showed that the cut-off value of CRP, Serum IL-6, Days from onset of Flu symptoms to hospitalization and CSF-TP were 7.57 mg/L, 9.84 pg/ml, 4.5 days and 194.8 mg/L, respectively.ConclusionChildren with severe influenza with CRP ≥ 7.57 mg/L, Serum IL-6 ≥ 9.84 pg/ml, Days from onset of Flu symptoms to hospitalization ≤4.5 days, CSF-TP ≥ 194.8 mg/L and FluA had a significantly increased risk of febrile seizures. It is useful for clinicians to determine the risk of severe influenza combined with febrile seizures, to adjust the early treatment plan, and to reduce the incidence of critically ill patients. |
| format | Article |
| id | doaj-art-ec467c33ea3049d6b0a1a4ac601d0cdc |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-ec467c33ea3049d6b0a1a4ac601d0cdc2025-08-20T02:09:47ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-10-011210.3389/fped.2024.14184991418499Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysisPeng Li0Peng Li1Mei Chen2Mei Chen3Daobin Wang4Xue Zhang5Ruiyang Sun6Wanyu Jia7Shuqin Fu8Junhao Cui9Chunlan Song10Chunlan Song11Pediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Provincial Engineering Research Center for Diagnosis and Treatment of Pediatric Infections and Critical Illnesses, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Provincial Engineering Research Center for Diagnosis and Treatment of Pediatric Infections and Critical Illnesses, Zhengzhou, Henan Province, ChinaPediatric Department, Zhecheng County People's Hospital, Shangqiu, Henan Province, ChinaPediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, ChinaPediatric Emergency Department, Henan Provincial Engineering Research Center for Diagnosis and Treatment of Pediatric Infections and Critical Illnesses, Zhengzhou, Henan Province, ChinaObjectiveTo retrospectively analyze the clinical characteristics and independent risk factors of severe influenza combined with febrile seizures, and to provide more basis for early clinical intervention.MethodsA total of 161 children with severe influenza were collected as study subjects and divided into convulsive (FC) group (40 cases) and non-convulsive (NFC) group (121 cases) according to whether they had febrile seizures. The demographic characteristics and clinical data of the two groups were analyzed. Multivariate logistic regression was used to analyze the risk factors of severe influenza combined with febrile seizures. The predictive efficacy was evaluated by receiver operating characteristic (ROC) curve analysis.Results(1) Multiple logistic regression analysis revealed that C-reactive protein (CRP) levels, Serum interleukin 6 (IL-6) levels, Days from onset of Flu symptoms to hospitalization, cerebrospinal fluid protein (CSF-TP) levels and the influenza virus type A (FluA) infection rate were found to be independent risk factors for severe influenza combined with febrile seizures in children. (2) ROC curve analysis showed that the cut-off value of CRP, Serum IL-6, Days from onset of Flu symptoms to hospitalization and CSF-TP were 7.57 mg/L, 9.84 pg/ml, 4.5 days and 194.8 mg/L, respectively.ConclusionChildren with severe influenza with CRP ≥ 7.57 mg/L, Serum IL-6 ≥ 9.84 pg/ml, Days from onset of Flu symptoms to hospitalization ≤4.5 days, CSF-TP ≥ 194.8 mg/L and FluA had a significantly increased risk of febrile seizures. It is useful for clinicians to determine the risk of severe influenza combined with febrile seizures, to adjust the early treatment plan, and to reduce the incidence of critically ill patients.https://www.frontiersin.org/articles/10.3389/fped.2024.1418499/fullinfluenzafebrile seizuresrisk factorsreceiver operating characteristic curvemultivariate logistic regression |
| spellingShingle | Peng Li Peng Li Mei Chen Mei Chen Daobin Wang Xue Zhang Ruiyang Sun Wanyu Jia Shuqin Fu Junhao Cui Chunlan Song Chunlan Song Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis Frontiers in Pediatrics influenza febrile seizures risk factors receiver operating characteristic curve multivariate logistic regression |
| title | Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis |
| title_full | Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis |
| title_fullStr | Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis |
| title_full_unstemmed | Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis |
| title_short | Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis |
| title_sort | clinical characteristics of severe influenza as a risk factor for febrile seizures in children a retrospective analysis |
| topic | influenza febrile seizures risk factors receiver operating characteristic curve multivariate logistic regression |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1418499/full |
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