Lipid droplet accumulation in microglia and their potential roles
Abstract Microglia are the resident immune cells of the central nervous system (CNS), where lipid metabolism is critical for maintaining homeostasis. In response to various external stimuli, they demonstrate a range of phenotypic expressions and lipid metabolic reprogramming. Lipid droplets (LDs) ar...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-025-02633-3 |
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| author | Yunxia Li Qi Zhao Yan Wang Wenyi Du Riyun Yang Jian Wu Yi Li |
| author_facet | Yunxia Li Qi Zhao Yan Wang Wenyi Du Riyun Yang Jian Wu Yi Li |
| author_sort | Yunxia Li |
| collection | DOAJ |
| description | Abstract Microglia are the resident immune cells of the central nervous system (CNS), where lipid metabolism is critical for maintaining homeostasis. In response to various external stimuli, they demonstrate a range of phenotypic expressions and lipid metabolic reprogramming. Lipid droplets (LDs) are dynamic organelles that function beyond energy storage, actively participating in neuropathological progress. Recent investigations have identified a subset of microglia characterized by the accumulation of LDs, referred to as “lipid-droplet-accumulating microglia” (LDAM). This review aims to investigate the processes involved in LD formation and degradation, the factors that modulate them, focusing particularly on the function of LDAM and their implications for CNS disorders. By synthesizing current evidence, we clarify the biological significance of LDs in these cells and their therapeutic targeting potential, providing new directions for future research. |
| format | Article |
| id | doaj-art-ec4286cb7b5b4eed955c718fc49945aa |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-ec4286cb7b5b4eed955c718fc49945aa2025-08-20T04:03:07ZengBMCLipids in Health and Disease1476-511X2025-06-0124111810.1186/s12944-025-02633-3Lipid droplet accumulation in microglia and their potential rolesYunxia Li0Qi Zhao1Yan Wang2Wenyi Du3Riyun Yang4Jian Wu5Yi Li6Department of Histology and Embryology, Medical College, Nantong UniversityDepartment of Histology and Embryology, Medical College, Nantong UniversityDepartment of Histology and Embryology, Medical College, Nantong UniversityDepartment of Histology and Embryology, Medical College, Nantong UniversityDepartment of Histology and Embryology, Medical College, Nantong UniversityDepartment of Histology and Embryology, Medical College, Nantong UniversityDepartment of Histology and Embryology, Medical College, Nantong UniversityAbstract Microglia are the resident immune cells of the central nervous system (CNS), where lipid metabolism is critical for maintaining homeostasis. In response to various external stimuli, they demonstrate a range of phenotypic expressions and lipid metabolic reprogramming. Lipid droplets (LDs) are dynamic organelles that function beyond energy storage, actively participating in neuropathological progress. Recent investigations have identified a subset of microglia characterized by the accumulation of LDs, referred to as “lipid-droplet-accumulating microglia” (LDAM). This review aims to investigate the processes involved in LD formation and degradation, the factors that modulate them, focusing particularly on the function of LDAM and their implications for CNS disorders. By synthesizing current evidence, we clarify the biological significance of LDs in these cells and their therapeutic targeting potential, providing new directions for future research.https://doi.org/10.1186/s12944-025-02633-3Lipid dropletsMicrogliaCentral nervous systemNeurological disordersLipid metabolism |
| spellingShingle | Yunxia Li Qi Zhao Yan Wang Wenyi Du Riyun Yang Jian Wu Yi Li Lipid droplet accumulation in microglia and their potential roles Lipids in Health and Disease Lipid droplets Microglia Central nervous system Neurological disorders Lipid metabolism |
| title | Lipid droplet accumulation in microglia and their potential roles |
| title_full | Lipid droplet accumulation in microglia and their potential roles |
| title_fullStr | Lipid droplet accumulation in microglia and their potential roles |
| title_full_unstemmed | Lipid droplet accumulation in microglia and their potential roles |
| title_short | Lipid droplet accumulation in microglia and their potential roles |
| title_sort | lipid droplet accumulation in microglia and their potential roles |
| topic | Lipid droplets Microglia Central nervous system Neurological disorders Lipid metabolism |
| url | https://doi.org/10.1186/s12944-025-02633-3 |
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