Helicobacter pylori Resistance to Antibiotics: Prevalence, Mechanism, Detection. What’s New?
Helicobacter pylori resistance to antibiotics is increasingly reported and may limit the efficacy of current treatment regimens. Their resistance mechanism has been found to be point mutations for all antibiotics. Macrolide resistance is the most clinically important, but can be detected efficiently...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/704035 |
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| Summary: | Helicobacter pylori resistance to antibiotics is increasingly reported
and may limit the efficacy of current treatment regimens. Their
resistance mechanism has been found to be point mutations for all
antibiotics. Macrolide resistance is the most clinically important, but
can be detected efficiently by molecular methods. Metronidazole
resistance has limited clinical impact but testing methods are not
reliable. Seldomly found cases of resistance, such as to amoxicillin
and tetracycline, have had their mechanism recently elucidated. The
existance of rapid and practical methods for the detection of
macrolide resistance (eg, Fluorescence Resonance Energy Transfer
assay) should improve management of H pylori-positive patients in
the future, by allowing an adapted first-line therapy. |
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| ISSN: | 0835-7900 |