Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells

Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells

Succinate dehydrogenase inhibitors (SDHi) are fungicides used worldwide to control the proliferation of fungi in crops. They act by blocking the activity of succinate dehydrogenase (SDH), a universal enzyme involved in mitochondrial functions and metabolism. While SDH-encoding genes are tumour suppr...

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Main Authors: Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Clémence Rives, Jules Imler, Sofiane Safi-Stibler, Lara Gales, Floriant Bellvert, Julien Dairou, Auriane Hagimont, Agnès Burel, Dominique Lagadic-Gossmann, Robert Barouki, Jerry W. Shay, Jean Bastin, Sophie Mouillet-Richard, Anthony Lemarié, Fatima Djouadi, Sandrine Ellero-Simatos, Xavier Coumoul, Judith Favier, Sylvie Bortoli
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Environment International
Subjects:
Pesticides
Mitochondria
Metabolic reprogramming
Cancer
Oncometabolite
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412025002545
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