Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress
Oxaliplatin, a third-generation platinum-based chemotherapeutic agent, has shown substantial efficacy in cancer treatment. However, its associated side effects, particularly chemotherapy-induced peripheral neuropathic pain (CIPNP), continue to challenge cancer survivors globally. Clinically, it freq...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1609791/full |
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| author | Yuxin Jiang Yuxin Jiang Jie Shi Wenping Wang Haozhe Piao Huini Yao Jun Yu Zhenzhu Zhai Qian Liu Ningxin Li Jiaqing Fu Yue Shen Shengbo Jin Shengbo Jin Mingzhu Li |
| author_facet | Yuxin Jiang Yuxin Jiang Jie Shi Wenping Wang Haozhe Piao Huini Yao Jun Yu Zhenzhu Zhai Qian Liu Ningxin Li Jiaqing Fu Yue Shen Shengbo Jin Shengbo Jin Mingzhu Li |
| author_sort | Yuxin Jiang |
| collection | DOAJ |
| description | Oxaliplatin, a third-generation platinum-based chemotherapeutic agent, has shown substantial efficacy in cancer treatment. However, its associated side effects, particularly chemotherapy-induced peripheral neuropathic pain (CIPNP), continue to challenge cancer survivors globally. Clinically, it frequently presents as numbness, coldness, and discomfort in the limbs and extremities. Duloxetine is advised for analgesic purposes. Despite its clinical relevance, both the application methods and the underlying mechanisms of oxaliplatin-induced CINP warrant further investigation. Consequently, more precise animal models are needed to explore the mechanisms and progression of this condition. This review consolidates recent advancements in rat and mouse models of oxaliplatin-induced CINP, with the aim of enhancing modeling success rates and developing models that more accurately mirror disease progression. Such models are essential for advancing clinical research and drug development. |
| format | Article |
| id | doaj-art-ec3a0fbc2c724aa79ea99997fb0b9c89 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-ec3a0fbc2c724aa79ea99997fb0b9c892025-08-20T02:16:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.16097911609791Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progressYuxin Jiang0Yuxin Jiang1Jie Shi2Wenping Wang3Haozhe Piao4Huini Yao5Jun Yu6Zhenzhu Zhai7Qian Liu8Ningxin Li9Jiaqing Fu10Yue Shen11Shengbo Jin12Shengbo Jin13Mingzhu Li14Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, ChinaCancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, ChinaDalian Medical University, Dalian, Liaoning, ChinaCancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, ChinaCancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, ChinaChina Medical University, Shenyang, Liaoning, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, ChinaChina Medical University, Shenyang, Liaoning, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, ChinaAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, College of Liaoning Chinese Traditional Medicine, Shenyang, Liaoning, ChinaCancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, ChinaOxaliplatin, a third-generation platinum-based chemotherapeutic agent, has shown substantial efficacy in cancer treatment. However, its associated side effects, particularly chemotherapy-induced peripheral neuropathic pain (CIPNP), continue to challenge cancer survivors globally. Clinically, it frequently presents as numbness, coldness, and discomfort in the limbs and extremities. Duloxetine is advised for analgesic purposes. Despite its clinical relevance, both the application methods and the underlying mechanisms of oxaliplatin-induced CINP warrant further investigation. Consequently, more precise animal models are needed to explore the mechanisms and progression of this condition. This review consolidates recent advancements in rat and mouse models of oxaliplatin-induced CINP, with the aim of enhancing modeling success rates and developing models that more accurately mirror disease progression. Such models are essential for advancing clinical research and drug development.https://www.frontiersin.org/articles/10.3389/fphar.2025.1609791/fulloxaliplatinneuropathic painCINP animal modelchemotherapyapplications |
| spellingShingle | Yuxin Jiang Yuxin Jiang Jie Shi Wenping Wang Haozhe Piao Huini Yao Jun Yu Zhenzhu Zhai Qian Liu Ningxin Li Jiaqing Fu Yue Shen Shengbo Jin Shengbo Jin Mingzhu Li Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress Frontiers in Pharmacology oxaliplatin neuropathic pain CINP animal model chemotherapy applications |
| title | Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress |
| title_full | Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress |
| title_fullStr | Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress |
| title_full_unstemmed | Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress |
| title_short | Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress |
| title_sort | oxaliplatin induced neuropathic pain in cancer animal models and related research progress |
| topic | oxaliplatin neuropathic pain CINP animal model chemotherapy applications |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1609791/full |
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