When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis

When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis

<b>Introduction:</b> Here we consider the collision of a genetic factor and an essential instigator in Alzheimer’s neuropathogenesis: (i) the Alzheimer’s gene (APOEε4), which downregulates lysosomal autophagy and induces synthesis of (ii) the instigator, interleukin-1β (IL-1β), which dri...

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Bibliographic Details
Main Authors: Jagadeesh Narasimhappagari, Ling Liu, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, W. Sue T. Griffin
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Cells
Subjects:
APOEε4
Interleukin-1β
Neuroinflammation
autophagy
Online Access:https://www.mdpi.com/2073-4409/14/15/1216
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