Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular Reorganization
Abstract During the first days of neonatal growth, the central nervous system (CNS) develops self‐regulatory mechanisms to ensure constant cerebral perfusion. However, this vascular neogenesis takes place at a microscopic scale that cannot be observed with current clinical imaging techniques. Ultras...
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Wiley
2025-03-01
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| Online Access: | https://doi.org/10.1002/advs.202415235 |
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| author | Simone Schwarz Louise Denis Emmanuel Nedoschill Adrian Buehler Vera Danko Alina C. Hilger Francisco Brevis Nuñez Nikola R. Dürr Martin Schlunz‐Hendann Friedhelm Brassel Ursula Felderhoff‐Müser Heiko Reutter Joachim Woelfle Jörg Jüngert Christian Dohna‐Schwake Nora Bruns Adrian P. Regensburger Olivier Couture Henriette Mandelbaum Ferdinand Knieling |
| author_facet | Simone Schwarz Louise Denis Emmanuel Nedoschill Adrian Buehler Vera Danko Alina C. Hilger Francisco Brevis Nuñez Nikola R. Dürr Martin Schlunz‐Hendann Friedhelm Brassel Ursula Felderhoff‐Müser Heiko Reutter Joachim Woelfle Jörg Jüngert Christian Dohna‐Schwake Nora Bruns Adrian P. Regensburger Olivier Couture Henriette Mandelbaum Ferdinand Knieling |
| author_sort | Simone Schwarz |
| collection | DOAJ |
| description | Abstract During the first days of neonatal growth, the central nervous system (CNS) develops self‐regulatory mechanisms to ensure constant cerebral perfusion. However, this vascular neogenesis takes place at a microscopic scale that cannot be observed with current clinical imaging techniques. Ultrasound localization microscopy (ULM) allows us to observe micro‐vessels of the order of a few microns at depths of several centimeters. This can be done using conventional clinical ultrasound scanners and contrast sequences (CEUS). In this study, ULM is used to observe the human microvasculature in neonatal patients undergoing treatment for life‐threatening malformations forming direct connections between the cerebral arterial and venous systems. It is observed that neuroendovascular treatment of neonatal arteriovenous malformations causes remodeling and reorganization of the cerebral vasculature by also activating corticomedullary vascular connections. ULM enables us to follow microvascular changes in human neonates with high spatio‐temporal resolution. ULM may provide a novel clinical translatable tool, particularly including cerebral imaging in very young patients. |
| format | Article |
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| issn | 2198-3844 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-ec2ec5dd090e464ca5726cf15984e3152025-08-20T01:49:42ZengWileyAdvanced Science2198-38442025-03-011212n/an/a10.1002/advs.202415235Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular ReorganizationSimone Schwarz0Louise Denis1Emmanuel Nedoschill2Adrian Buehler3Vera Danko4Alina C. Hilger5Francisco Brevis Nuñez6Nikola R. Dürr7Martin Schlunz‐Hendann8Friedhelm Brassel9Ursula Felderhoff‐Müser10Heiko Reutter11Joachim Woelfle12Jörg Jüngert13Christian Dohna‐Schwake14Nora Bruns15Adrian P. Regensburger16Olivier Couture17Henriette Mandelbaum18Ferdinand Knieling19Department of Neonatology and Pediatric Intensive Care Medicine Sana Clinics Duisburg Zu den Rehwiesen 9 47055 Duisburg GermanyLaboratoire d'Imagerie Biomédicale Sorbonne Université CNRS INSERM 15 Rue de l'Ecole de Médecine 75006 Paris FranceDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Neonatology and Pediatric Intensive Care Medicine Sana Clinics Duisburg Zu den Rehwiesen 9 47055 Duisburg GermanyClinic for Radiology and Neuroradiology Sana Clinics Duisburg Zu den Rehwiesen 9 47055 Duisburg GermanyClinic for Radiology and Neuroradiology Sana Clinics Duisburg Zu den Rehwiesen 9 47055 Duisburg GermanyClinic for Radiology and Neuroradiology Sana Clinics Duisburg Zu den Rehwiesen 9 47055 Duisburg GermanyDepartment of Pediatrics I University Hospital Essen University of Duisburg‐Essen Hufelandstraße 55 45147 Essen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Pediatrics I University Hospital Essen University of Duisburg‐Essen Hufelandstraße 55 45147 Essen GermanyDepartment of Pediatrics I University Hospital Essen University of Duisburg‐Essen Hufelandstraße 55 45147 Essen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyLaboratoire d'Imagerie Biomédicale Sorbonne Université CNRS INSERM 15 Rue de l'Ecole de Médecine 75006 Paris FranceDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyDepartment of Pediatrics and Adolescent Medicine University Hospital Erlangen Loschgestraße 15 91054 Erlangen GermanyAbstract During the first days of neonatal growth, the central nervous system (CNS) develops self‐regulatory mechanisms to ensure constant cerebral perfusion. However, this vascular neogenesis takes place at a microscopic scale that cannot be observed with current clinical imaging techniques. Ultrasound localization microscopy (ULM) allows us to observe micro‐vessels of the order of a few microns at depths of several centimeters. This can be done using conventional clinical ultrasound scanners and contrast sequences (CEUS). In this study, ULM is used to observe the human microvasculature in neonatal patients undergoing treatment for life‐threatening malformations forming direct connections between the cerebral arterial and venous systems. It is observed that neuroendovascular treatment of neonatal arteriovenous malformations causes remodeling and reorganization of the cerebral vasculature by also activating corticomedullary vascular connections. ULM enables us to follow microvascular changes in human neonates with high spatio‐temporal resolution. ULM may provide a novel clinical translatable tool, particularly including cerebral imaging in very young patients.https://doi.org/10.1002/advs.202415235CEUSmicrobubblessuper‐resolution imagingultrasound localization microscopyultrasoundVein of Galen malformation |
| spellingShingle | Simone Schwarz Louise Denis Emmanuel Nedoschill Adrian Buehler Vera Danko Alina C. Hilger Francisco Brevis Nuñez Nikola R. Dürr Martin Schlunz‐Hendann Friedhelm Brassel Ursula Felderhoff‐Müser Heiko Reutter Joachim Woelfle Jörg Jüngert Christian Dohna‐Schwake Nora Bruns Adrian P. Regensburger Olivier Couture Henriette Mandelbaum Ferdinand Knieling Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular Reorganization Advanced Science CEUS microbubbles super‐resolution imaging ultrasound localization microscopy ultrasound Vein of Galen malformation |
| title | Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular Reorganization |
| title_full | Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular Reorganization |
| title_fullStr | Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular Reorganization |
| title_full_unstemmed | Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular Reorganization |
| title_short | Ultrasound Super‐Resolution Imaging of Neonatal Cerebral Vascular Reorganization |
| title_sort | ultrasound super resolution imaging of neonatal cerebral vascular reorganization |
| topic | CEUS microbubbles super‐resolution imaging ultrasound localization microscopy ultrasound Vein of Galen malformation |
| url | https://doi.org/10.1002/advs.202415235 |
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