Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study
Background: Multiple myeloma (MM) is characterized by reduced circulating adiponectin levels, a condition associated with various diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer, and plasma dyscrasias. Curcumin has been shown to inhibit adipogenesis and elevate serum adi...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2025-03-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-4177-en.pdf |
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| author | Damai Santosa Damar Mashkun Rizqi Eko Adhi Pangarsa Budi Setiawan Suyono Suyono Mika Lumban Tobing Suhartono Suhartono Soeharyo Hadisaputro Ignatius Riwanto Aru Wisaksono Sudoyo Catharina Suharti |
| author_facet | Damai Santosa Damar Mashkun Rizqi Eko Adhi Pangarsa Budi Setiawan Suyono Suyono Mika Lumban Tobing Suhartono Suhartono Soeharyo Hadisaputro Ignatius Riwanto Aru Wisaksono Sudoyo Catharina Suharti |
| author_sort | Damai Santosa |
| collection | DOAJ |
| description | Background: Multiple myeloma (MM) is characterized by reduced circulating adiponectin levels, a condition associated with various diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer, and plasma dyscrasias. Curcumin has been shown to inhibit adipogenesis and elevate serum adiponectin levels. Notably, limited studies investigating the relationship between adiponectin levels and curcumin supplementation in myeloma patients. This study is to evaluate the efficacy curcumin supplements on increasing the levels of adiponectin in myeloma patients
Methods: Patients with myeloma were randomly to melphalan, prednisone, curcumin (MPC) (n=17) and melphalan with prednisone (MP) (n=16) groups. The MPC group was treated by melphalan 4 mg/m2 and prednisone 40 mg/m2 for 7 days (MP), and curcumin 8 grams daily for 28 days. The MP group received MP and placebo. Subjects were followed-up every 28 days and a total of four treatment cycles. Hemoglobin, albumin, white blood cell (WBC), platelets, urea, creatinine, calcium, protein M, and adiponectin evaluated before and after treatment. Mann Whitney test or the Independent T-test were used to analysis
Results: Total subject (24 subjects) completed the treatment. Serum adiponectin levels after four treatment cycles in the MPC group were higher than in the MP group [(mean, 12227.1±5748.3) vs (11365.4±9175.5), P = 0.78]
Conclusion: Supplementing MP regimen with 8000 mg curcumin daily for 28 days increases the serum adiponectin level after four treatment cycles in myeloma patients. This research found that myeloma patients may benefit by taking curcumin supplementation. |
| format | Article |
| id | doaj-art-ec268d881ffe4b61899aaa9d32dfc330 |
| institution | DOAJ |
| issn | 2008-6164 2008-6172 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj-art-ec268d881ffe4b61899aaa9d32dfc3302025-08-20T03:17:51ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722025-03-01162320327Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot studyDamai Santosa0Damar Mashkun Rizqi1Eko Adhi Pangarsa2Budi Setiawan3Suyono Suyono4Mika Lumban Tobing5Suhartono Suhartono6Soeharyo Hadisaputro7Ignatius Riwanto8Aru Wisaksono Sudoyo9Catharina Suharti10 Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Department of Internal Medicine, RSUD Hj. Anna Lasmanah Banjarnegara, Jawa Tengah, Indonesia Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Department of Environmental Health, Faculty of Public Health, Diponegoro University, Jawa Tengah, Indonesia Division of Topical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Department of Surgery, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Background: Multiple myeloma (MM) is characterized by reduced circulating adiponectin levels, a condition associated with various diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer, and plasma dyscrasias. Curcumin has been shown to inhibit adipogenesis and elevate serum adiponectin levels. Notably, limited studies investigating the relationship between adiponectin levels and curcumin supplementation in myeloma patients. This study is to evaluate the efficacy curcumin supplements on increasing the levels of adiponectin in myeloma patients Methods: Patients with myeloma were randomly to melphalan, prednisone, curcumin (MPC) (n=17) and melphalan with prednisone (MP) (n=16) groups. The MPC group was treated by melphalan 4 mg/m2 and prednisone 40 mg/m2 for 7 days (MP), and curcumin 8 grams daily for 28 days. The MP group received MP and placebo. Subjects were followed-up every 28 days and a total of four treatment cycles. Hemoglobin, albumin, white blood cell (WBC), platelets, urea, creatinine, calcium, protein M, and adiponectin evaluated before and after treatment. Mann Whitney test or the Independent T-test were used to analysis Results: Total subject (24 subjects) completed the treatment. Serum adiponectin levels after four treatment cycles in the MPC group were higher than in the MP group [(mean, 12227.1±5748.3) vs (11365.4±9175.5), P = 0.78] Conclusion: Supplementing MP regimen with 8000 mg curcumin daily for 28 days increases the serum adiponectin level after four treatment cycles in myeloma patients. This research found that myeloma patients may benefit by taking curcumin supplementation.http://caspjim.com/article-1-4177-en.pdfmultiple myelomacurcuminadiponectin |
| spellingShingle | Damai Santosa Damar Mashkun Rizqi Eko Adhi Pangarsa Budi Setiawan Suyono Suyono Mika Lumban Tobing Suhartono Suhartono Soeharyo Hadisaputro Ignatius Riwanto Aru Wisaksono Sudoyo Catharina Suharti Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study Caspian Journal of Internal Medicine multiple myeloma curcumin adiponectin |
| title | Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study |
| title_full | Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study |
| title_fullStr | Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study |
| title_full_unstemmed | Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study |
| title_short | Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study |
| title_sort | adiponectin levels in myeloma patients after curcumin supplementation a randomized clinical pilot study |
| topic | multiple myeloma curcumin adiponectin |
| url | http://caspjim.com/article-1-4177-en.pdf |
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