Molecular basis of human essential hypertension.
Essential hypertension (HTN) affects over one billion people worldwide. It is a complex, multifactorial, quantitative trait under polygenic control resulting from inheritance of a number of susceptibility genes and involves multiple environmental determinants in different combinations in different...
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2011-12-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/20 |
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| _version_ | 1850188845980581888 |
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| author | Sadiqa Syed Masood A Qureshi |
| author_facet | Sadiqa Syed Masood A Qureshi |
| author_sort | Sadiqa Syed |
| collection | DOAJ |
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Essential hypertension (HTN) affects over one billion people worldwide. It is a complex, multifactorial, quantitative trait under polygenic control resulting from inheritance of a number of susceptibility genes and involves multiple environmental determinants in different combinations in different individuals. The completion of the draft sequence of human genome and recent advances in the genetics have resulted in identification and characterization of various genetic mechanisms that associate increased blood pressure and cardiovascular risk factors. The possible molecular mechanisms involved in homeostasis, ranging from locally acting vasoactive peptides to components of rennin angiotensin aldosterone system to epithelial sodium channels and sodium chloride transporters have been discussed. Several vasoregulatory systems including sympathetic vasoregulation and cytokines release have been studied extensively. Despite all these efforts of identification of numerous candidate genes in different ethnic populations using different approaches and technologies, the results are still inconsistent and the genetic and molecular basis of HTN remains unclear. In view of rapid availability of useful data on various aspects of Physiology and genetics of HTN, it is pertinent to review such information focusing on association of well known candidate genes with various facets of HTN and their physiological regulatory processes. Thus HTN related risk factors, known to have interactions with genes are highlighted in this article.
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| format | Article |
| id | doaj-art-ec1f877a3ca14145a878b0f07431bba4 |
| institution | OA Journals |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2011-12-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-ec1f877a3ca14145a878b0f07431bba42025-08-20T02:15:46ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822011-12-0112Molecular basis of human essential hypertension.Sadiqa SyedMasood A Qureshi Essential hypertension (HTN) affects over one billion people worldwide. It is a complex, multifactorial, quantitative trait under polygenic control resulting from inheritance of a number of susceptibility genes and involves multiple environmental determinants in different combinations in different individuals. The completion of the draft sequence of human genome and recent advances in the genetics have resulted in identification and characterization of various genetic mechanisms that associate increased blood pressure and cardiovascular risk factors. The possible molecular mechanisms involved in homeostasis, ranging from locally acting vasoactive peptides to components of rennin angiotensin aldosterone system to epithelial sodium channels and sodium chloride transporters have been discussed. Several vasoregulatory systems including sympathetic vasoregulation and cytokines release have been studied extensively. Despite all these efforts of identification of numerous candidate genes in different ethnic populations using different approaches and technologies, the results are still inconsistent and the genetic and molecular basis of HTN remains unclear. In view of rapid availability of useful data on various aspects of Physiology and genetics of HTN, it is pertinent to review such information focusing on association of well known candidate genes with various facets of HTN and their physiological regulatory processes. Thus HTN related risk factors, known to have interactions with genes are highlighted in this article. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/20Genome, locus, hypertension, candidate genes |
| spellingShingle | Sadiqa Syed Masood A Qureshi Molecular basis of human essential hypertension. Journal of Bahria University Medical and Dental College Genome, locus, hypertension, candidate genes |
| title | Molecular basis of human essential hypertension. |
| title_full | Molecular basis of human essential hypertension. |
| title_fullStr | Molecular basis of human essential hypertension. |
| title_full_unstemmed | Molecular basis of human essential hypertension. |
| title_short | Molecular basis of human essential hypertension. |
| title_sort | molecular basis of human essential hypertension |
| topic | Genome, locus, hypertension, candidate genes |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/20 |
| work_keys_str_mv | AT sadiqasyed molecularbasisofhumanessentialhypertension AT masoodaqureshi molecularbasisofhumanessentialhypertension |