Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population study
Previous studies have established a correlation between thyroid dysfunction and liver diseases. Environmental Water Iodine, a crucial source of iodine intake, has shown a U-shaped relationship with the occurrence of thyroid diseases. Nevertheless, the precise connection between different environment...
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2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325011121 |
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| author | Yun Chen Xinyi Bai Yanhong He Wenjing Che Zheng Zhou Haiyan Gao Yan Zhang Yao Chen Qingzhen Jia Lixiang Liu Hongmei Shen |
| author_facet | Yun Chen Xinyi Bai Yanhong He Wenjing Che Zheng Zhou Haiyan Gao Yan Zhang Yao Chen Qingzhen Jia Lixiang Liu Hongmei Shen |
| author_sort | Yun Chen |
| collection | DOAJ |
| description | Previous studies have established a correlation between thyroid dysfunction and liver diseases. Environmental Water Iodine, a crucial source of iodine intake, has shown a U-shaped relationship with the occurrence of thyroid diseases. Nevertheless, the precise connection between different environmental water iodine concentrations (WIC) and liver function remains unclear.Thus, a cross-sectional study was conducted in regions with varying levels of unimproved water supplies, categorized by WIC: < 10 µg/L, 40–100 µg/L, and > 100 µg/L. This study compared the serum levels of liver function markers including alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) were compared among populations in areas with different water iodine concentrations. Significant differences were found in the levels of AST, ALP, TP, ALB, TBIL, DBIL, and IBIL. Based on different WIC, the chi-square test was employed to assess the prevalence of abnormal circulating liver function indicators. To further explore the association between different environmental WIC and these abnormal circulating liver function indicators, a logistic regression model was employed in this investigation. The results showed that following adjustment for potential confounders, both WIC< 10 µg/L and WIC> 100 µg/L were significantly negatively correlated with abnormal serum TP and ALB levels [WIC< 10 µg/L: odds ratio (OR), 3.147 (1.828,5.604), P < 0.001, OR, 4.149 (2.246,8.146), P < 0.001; WIC> 100 µg/L: OR, 2.456 (1.394,4.435), P = 0.002, OR, 2.211 (1.151, 4.425), P = 0.020]. Mediation analysis indicated direct associations between WIC and abnormal serum TP and ALB levels. Additionally, after excluding participants with thyroid dysfunction, identical analyses were conducted, and the observed associations showed no substantial changes in their nature.In conclusion, environmental WIC exposure was closely associated with abnormal liver function, showing a U-shaped association with abnormal serum TP and ALB levels. However, given the observational nature of this study, further mechanistic validation is warranted through in vivo and in vitro experiments to delineate the causal relationship. |
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| spelling | doaj-art-ec1f45836f8345db8675b1fe3e0ca28f2025-08-20T03:41:31ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211876710.1016/j.ecoenv.2025.118767Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population studyYun Chen0Xinyi Bai1Yanhong He2Wenjing Che3Zheng Zhou4Haiyan Gao5Yan Zhang6Yao Chen7Qingzhen Jia8Lixiang Liu9Hongmei Shen10Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; The Sixth Affiated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaInstitute for Endemic Disease Prevention and Treatment of Shanxi Province, Linfen City, Shanxi Province 041000, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of ChinaCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China; Corresponding author at: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, People's Republic of China.Previous studies have established a correlation between thyroid dysfunction and liver diseases. Environmental Water Iodine, a crucial source of iodine intake, has shown a U-shaped relationship with the occurrence of thyroid diseases. Nevertheless, the precise connection between different environmental water iodine concentrations (WIC) and liver function remains unclear.Thus, a cross-sectional study was conducted in regions with varying levels of unimproved water supplies, categorized by WIC: < 10 µg/L, 40–100 µg/L, and > 100 µg/L. This study compared the serum levels of liver function markers including alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) were compared among populations in areas with different water iodine concentrations. Significant differences were found in the levels of AST, ALP, TP, ALB, TBIL, DBIL, and IBIL. Based on different WIC, the chi-square test was employed to assess the prevalence of abnormal circulating liver function indicators. To further explore the association between different environmental WIC and these abnormal circulating liver function indicators, a logistic regression model was employed in this investigation. The results showed that following adjustment for potential confounders, both WIC< 10 µg/L and WIC> 100 µg/L were significantly negatively correlated with abnormal serum TP and ALB levels [WIC< 10 µg/L: odds ratio (OR), 3.147 (1.828,5.604), P < 0.001, OR, 4.149 (2.246,8.146), P < 0.001; WIC> 100 µg/L: OR, 2.456 (1.394,4.435), P = 0.002, OR, 2.211 (1.151, 4.425), P = 0.020]. Mediation analysis indicated direct associations between WIC and abnormal serum TP and ALB levels. Additionally, after excluding participants with thyroid dysfunction, identical analyses were conducted, and the observed associations showed no substantial changes in their nature.In conclusion, environmental WIC exposure was closely associated with abnormal liver function, showing a U-shaped association with abnormal serum TP and ALB levels. However, given the observational nature of this study, further mechanistic validation is warranted through in vivo and in vitro experiments to delineate the causal relationship.http://www.sciencedirect.com/science/article/pii/S0147651325011121Environmental water iodineAbnormal circulating liver functionTPALB |
| spellingShingle | Yun Chen Xinyi Bai Yanhong He Wenjing Che Zheng Zhou Haiyan Gao Yan Zhang Yao Chen Qingzhen Jia Lixiang Liu Hongmei Shen Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population study Ecotoxicology and Environmental Safety Environmental water iodine Abnormal circulating liver function TP ALB |
| title | Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population study |
| title_full | Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population study |
| title_fullStr | Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population study |
| title_full_unstemmed | Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population study |
| title_short | Association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross-sectional chinese population study |
| title_sort | association of environmental water iodine concentration with abnormal circulating liver function indicators in a cross sectional chinese population study |
| topic | Environmental water iodine Abnormal circulating liver function TP ALB |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325011121 |
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