Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study
Abstract The association between chronic kidney disease (CKD) and the risk of age-related macular degeneration (AMD) is unclear. Our study aimed to evaluate this relationship considering the potential impact of proteinuria. This retrospective cohort study used a large representative population sampl...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-12297-9 |
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| author | Junhee Park Kyungdo Han Bongseong Kim Kyungho Lee Hye Ryoun Jang Je Moon Yoon Dong Hui Lim Dong Wook Shin |
| author_facet | Junhee Park Kyungdo Han Bongseong Kim Kyungho Lee Hye Ryoun Jang Je Moon Yoon Dong Hui Lim Dong Wook Shin |
| author_sort | Junhee Park |
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| description | Abstract The association between chronic kidney disease (CKD) and the risk of age-related macular degeneration (AMD) is unclear. Our study aimed to evaluate this relationship considering the potential impact of proteinuria. This retrospective cohort study used a large representative population sample from the Korean National Health Insurance Service database (2009–2019) of individuals who participated in a national health screening program in 2009. CKD was determined by estimated glomerular filtration rate (eGFR). Proteinuria was assessed using dipstick urinalysis. AMD was identified according to International Classification Disease, Tenth Revision, codes in claims data. The Cox regression hazards model was used to estimate the association between CKD and risk of AMD. Among 4,005,946 participants, 400,189 (10.0%) had CKD. There was no significant association between CKD and AMD, but a positive relationship was identified between proteinuria and AMD. In stratification analysis with age and sex, the risk of AMD was more evident in younger (< 65 years) than older individuals (P-interaction < 0.001) and in men than women (P-interaction < 0.001). A positive association between proteinuria and AMD risk was observed and was prominent in younger males. |
| format | Article |
| id | doaj-art-ec1f2d72ab454b05a8bf3cc4454b8e27 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-ec1f2d72ab454b05a8bf3cc4454b8e272025-08-20T03:45:57ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-12297-9Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort studyJunhee Park0Kyungdo Han1Bongseong Kim2Kyungho Lee3Hye Ryoun Jang4Je Moon Yoon5Dong Hui Lim6Dong Wook Shin7Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Statistics and Actuarial Science, Soongsil UniversityDepartment of Statistics and Actuarial Science, Soongsil UniversityDivision of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityAbstract The association between chronic kidney disease (CKD) and the risk of age-related macular degeneration (AMD) is unclear. Our study aimed to evaluate this relationship considering the potential impact of proteinuria. This retrospective cohort study used a large representative population sample from the Korean National Health Insurance Service database (2009–2019) of individuals who participated in a national health screening program in 2009. CKD was determined by estimated glomerular filtration rate (eGFR). Proteinuria was assessed using dipstick urinalysis. AMD was identified according to International Classification Disease, Tenth Revision, codes in claims data. The Cox regression hazards model was used to estimate the association between CKD and risk of AMD. Among 4,005,946 participants, 400,189 (10.0%) had CKD. There was no significant association between CKD and AMD, but a positive relationship was identified between proteinuria and AMD. In stratification analysis with age and sex, the risk of AMD was more evident in younger (< 65 years) than older individuals (P-interaction < 0.001) and in men than women (P-interaction < 0.001). A positive association between proteinuria and AMD risk was observed and was prominent in younger males.https://doi.org/10.1038/s41598-025-12297-9Age-related macular degenerationChronic kidney diseaseGlomerular filtration rateProteinuria |
| spellingShingle | Junhee Park Kyungdo Han Bongseong Kim Kyungho Lee Hye Ryoun Jang Je Moon Yoon Dong Hui Lim Dong Wook Shin Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study Scientific Reports Age-related macular degeneration Chronic kidney disease Glomerular filtration rate Proteinuria |
| title | Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study |
| title_full | Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study |
| title_fullStr | Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study |
| title_full_unstemmed | Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study |
| title_short | Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study |
| title_sort | risk of age related macular degeneration according to the chronic kidney disease and proteinuria in korea a 10 year nationwide cohort study |
| topic | Age-related macular degeneration Chronic kidney disease Glomerular filtration rate Proteinuria |
| url | https://doi.org/10.1038/s41598-025-12297-9 |
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