The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction

Background. When compared to left ventricular ejection fraction (LVEF), previous studies have suggested the superiority of wall motion score index (WMSI) in predicting cardiac events in patients who have suffered acute myocardial infarction. However, there are limited studies assessing WMSI and mort...

Full description

Saved in:
Bibliographic Details
Main Authors: Michael L. Savage, Karen Hay, Bonita Anderson, Gregory Scalia, Darryl Burstow, Dale Murdoch, Isuru Ranasinghe, Owen Christopher Raffel
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Critical Care Research and Practice
Online Access:http://dx.doi.org/10.1155/2022/8343785
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832552952063066112
author Michael L. Savage
Karen Hay
Bonita Anderson
Gregory Scalia
Darryl Burstow
Dale Murdoch
Isuru Ranasinghe
Owen Christopher Raffel
author_facet Michael L. Savage
Karen Hay
Bonita Anderson
Gregory Scalia
Darryl Burstow
Dale Murdoch
Isuru Ranasinghe
Owen Christopher Raffel
author_sort Michael L. Savage
collection DOAJ
description Background. When compared to left ventricular ejection fraction (LVEF), previous studies have suggested the superiority of wall motion score index (WMSI) in predicting cardiac events in patients who have suffered acute myocardial infarction. However, there are limited studies assessing WMSI and mortality in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the prognostic value of WMSI in a cohort of STEMI patients treated with primary percutaneous coronary intervention (PCI). Methods. A comparison of WMSI, LVEF, and all-cause mortality in STEMI patients treated with primary PCI between January 2008 and December 2020 was performed. The prognostic value of WMSI, LVEF, and traditional risk scores (TIMI, GRACE) were compared using multivariable logistic regression modelling. Results. Among 1181 patients, 27 died within 30-days (2.3%) and 49 died within 12 months (4.2%). WMSI ≥1.8 was associated with poorer survival at 12-months (9.2% vs 1.5%; p<0.001). When used as the only classifier for predicting 12-month mortality, the discriminatory ability of WMSI (area under the curve (AUC): 0.77; 95% CI: 0.68–0.84) was significantly better than LVEF (AUC: 0.71; 95% CI: 0.61–0.79; p=0.034). After multivariable modelling, the AUC was comparable between models with either WMSI (AUC: 0.89; 95% CI: 0.85–0.94) or LVEF (AUC: 0.87; 95% CI: 0.83–0.92; p<0.08) yet performed significantly better than TIMI (AUC: 0.71; 95% CI: 0.62–0.79; p<0.001), or GRACE (AUC: 0.63; 95% CI: 0.54–0.71; p<0.001) risk scores. Conclusions. When examined individually, WMSI is a superior predictor of 12-month mortality over LVEF in STEMI patients treated with primary PCI. When examined in multivariable predictive models, WMSI and LVEF perform very well at predicting 12-month mortality, especially when compared to existing STEMI risk scores.
format Article
id doaj-art-ec1af620a5564c608e5c586080c45fa5
institution Kabale University
issn 2090-1313
language English
publishDate 2022-01-01
publisher Wiley
record_format Article
series Critical Care Research and Practice
spelling doaj-art-ec1af620a5564c608e5c586080c45fa52025-02-03T05:57:29ZengWileyCritical Care Research and Practice2090-13132022-01-01202210.1155/2022/8343785The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial InfarctionMichael L. Savage0Karen Hay1Bonita Anderson2Gregory Scalia3Darryl Burstow4Dale Murdoch5Isuru Ranasinghe6Owen Christopher Raffel7Cardiology DepartmentCardiology DepartmentCardiology DepartmentCardiology DepartmentCardiology DepartmentCardiology DepartmentCardiology DepartmentCardiology DepartmentBackground. When compared to left ventricular ejection fraction (LVEF), previous studies have suggested the superiority of wall motion score index (WMSI) in predicting cardiac events in patients who have suffered acute myocardial infarction. However, there are limited studies assessing WMSI and mortality in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the prognostic value of WMSI in a cohort of STEMI patients treated with primary percutaneous coronary intervention (PCI). Methods. A comparison of WMSI, LVEF, and all-cause mortality in STEMI patients treated with primary PCI between January 2008 and December 2020 was performed. The prognostic value of WMSI, LVEF, and traditional risk scores (TIMI, GRACE) were compared using multivariable logistic regression modelling. Results. Among 1181 patients, 27 died within 30-days (2.3%) and 49 died within 12 months (4.2%). WMSI ≥1.8 was associated with poorer survival at 12-months (9.2% vs 1.5%; p<0.001). When used as the only classifier for predicting 12-month mortality, the discriminatory ability of WMSI (area under the curve (AUC): 0.77; 95% CI: 0.68–0.84) was significantly better than LVEF (AUC: 0.71; 95% CI: 0.61–0.79; p=0.034). After multivariable modelling, the AUC was comparable between models with either WMSI (AUC: 0.89; 95% CI: 0.85–0.94) or LVEF (AUC: 0.87; 95% CI: 0.83–0.92; p<0.08) yet performed significantly better than TIMI (AUC: 0.71; 95% CI: 0.62–0.79; p<0.001), or GRACE (AUC: 0.63; 95% CI: 0.54–0.71; p<0.001) risk scores. Conclusions. When examined individually, WMSI is a superior predictor of 12-month mortality over LVEF in STEMI patients treated with primary PCI. When examined in multivariable predictive models, WMSI and LVEF perform very well at predicting 12-month mortality, especially when compared to existing STEMI risk scores.http://dx.doi.org/10.1155/2022/8343785
spellingShingle Michael L. Savage
Karen Hay
Bonita Anderson
Gregory Scalia
Darryl Burstow
Dale Murdoch
Isuru Ranasinghe
Owen Christopher Raffel
The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
Critical Care Research and Practice
title The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
title_full The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
title_fullStr The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
title_full_unstemmed The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
title_short The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
title_sort prognostic value of echocardiographic wall motion score index in st segment elevation myocardial infarction
url http://dx.doi.org/10.1155/2022/8343785
work_keys_str_mv AT michaellsavage theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT karenhay theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT bonitaanderson theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT gregoryscalia theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT darrylburstow theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT dalemurdoch theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT isururanasinghe theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT owenchristopherraffel theprognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT michaellsavage prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT karenhay prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT bonitaanderson prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT gregoryscalia prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT darrylburstow prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT dalemurdoch prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT isururanasinghe prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction
AT owenchristopherraffel prognosticvalueofechocardiographicwallmotionscoreindexinstsegmentelevationmyocardialinfarction