Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and Flaviviruses
Emerging RNA viruses such as influenza A virus (IAV), Zika virus (ZIKV), and dengue virus (DENV) continue to pose major challenges to animal and public health due to their high mutation rates, wide host ranges, and immune evasion strategies. In this study, we evaluated the in vitro antiviral activit...
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MDPI AG
2025-07-01
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| Online Access: | https://www.mdpi.com/2076-2615/15/14/2125 |
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| author | Kyeong-Seo Moon Ji-Young Chung Hyeon Jeong Moon Gun Lee Chung-Do Lee Su-Bin Jung Hyo-Jin Kim Jun-Gyu Park Yeong-Bin Baek Sang-Ik Park |
| author_facet | Kyeong-Seo Moon Ji-Young Chung Hyeon Jeong Moon Gun Lee Chung-Do Lee Su-Bin Jung Hyo-Jin Kim Jun-Gyu Park Yeong-Bin Baek Sang-Ik Park |
| author_sort | Kyeong-Seo Moon |
| collection | DOAJ |
| description | Emerging RNA viruses such as influenza A virus (IAV), Zika virus (ZIKV), and dengue virus (DENV) continue to pose major challenges to animal and public health due to their high mutation rates, wide host ranges, and immune evasion strategies. In this study, we evaluated the in vitro antiviral activity of a marine bacterial extract derived from <i>Parerythrobacter</i> sp. M20A3S10 against IAV (H1N1; H3N2), influenza B virus (IBV), ZIKV, and DENV2. The extract demonstrated broad-spectrum antiviral effects with favorable selectivity indices across multiple host-derived epithelial cell lines. Notably, post-infection treatment significantly suppressed viral replication, suggesting a host-modulating or replication-inhibiting mechanism. While the extract’s active components have yet to be identified, bacteria from the <i>Erythrobacteraceae</i> family are known producers of bioactive metabolites with potential antiviral properties. These findings provide preliminary insight into the potential of marine-derived bacterial compounds in veterinary antiviral development and highlight the need for further characterization and in vivo validation. This work contributes to the understanding of virus–host interactions and the exploration of novel therapeutic strategies targeting the pathogenesis and immune modulation of veterinary RNA viruses. |
| format | Article |
| id | doaj-art-ec0d95d31da3464898fe005066c368a5 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-ec0d95d31da3464898fe005066c368a52025-08-20T03:55:49ZengMDPI AGAnimals2076-26152025-07-011514212510.3390/ani15142125Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and FlavivirusesKyeong-Seo Moon0Ji-Young Chung1Hyeon Jeong Moon2Gun Lee3Chung-Do Lee4Su-Bin Jung5Hyo-Jin Kim6Jun-Gyu Park7Yeong-Bin Baek8Sang-Ik Park9Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaJeollanamdo Veterinary Service Laboratory, Gangjin 59213, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of KoreaEmerging RNA viruses such as influenza A virus (IAV), Zika virus (ZIKV), and dengue virus (DENV) continue to pose major challenges to animal and public health due to their high mutation rates, wide host ranges, and immune evasion strategies. In this study, we evaluated the in vitro antiviral activity of a marine bacterial extract derived from <i>Parerythrobacter</i> sp. M20A3S10 against IAV (H1N1; H3N2), influenza B virus (IBV), ZIKV, and DENV2. The extract demonstrated broad-spectrum antiviral effects with favorable selectivity indices across multiple host-derived epithelial cell lines. Notably, post-infection treatment significantly suppressed viral replication, suggesting a host-modulating or replication-inhibiting mechanism. While the extract’s active components have yet to be identified, bacteria from the <i>Erythrobacteraceae</i> family are known producers of bioactive metabolites with potential antiviral properties. These findings provide preliminary insight into the potential of marine-derived bacterial compounds in veterinary antiviral development and highlight the need for further characterization and in vivo validation. This work contributes to the understanding of virus–host interactions and the exploration of novel therapeutic strategies targeting the pathogenesis and immune modulation of veterinary RNA viruses.https://www.mdpi.com/2076-2615/15/14/2125marine bacteriuminfluenza virusZika virusdengue virusapoptosisbroad antiviral activity |
| spellingShingle | Kyeong-Seo Moon Ji-Young Chung Hyeon Jeong Moon Gun Lee Chung-Do Lee Su-Bin Jung Hyo-Jin Kim Jun-Gyu Park Yeong-Bin Baek Sang-Ik Park Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and Flaviviruses Animals marine bacterium influenza virus Zika virus dengue virus apoptosis broad antiviral activity |
| title | Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and Flaviviruses |
| title_full | Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and Flaviviruses |
| title_fullStr | Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and Flaviviruses |
| title_full_unstemmed | Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and Flaviviruses |
| title_short | Therapeutic Use of <i>Parerythrobacter</i> sp. M20A3S10, a Marine Bacterium, Targeting Influenza Viruses and Flaviviruses |
| title_sort | therapeutic use of i parerythrobacter i sp m20a3s10 a marine bacterium targeting influenza viruses and flaviviruses |
| topic | marine bacterium influenza virus Zika virus dengue virus apoptosis broad antiviral activity |
| url | https://www.mdpi.com/2076-2615/15/14/2125 |
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