VEXAS Syndrome and Alzheimer’s Disease—Are There Connections?

VEXAS Syndrome and Alzheimer’s Disease—Are There Connections?

VEXAS syndrome and Alzheimer’s disease (AD), though distinct in clinical manifestations, share overlapping pathophysiological mechanisms, including systemic inflammation, protein misfolding, and vascular dysfunction. VEXAS syndrome, a rare autoinflammatory disorder characterized by somatic UBA1 muta...

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Bibliographic Details
Main Authors: Aleksandra Sowa, Marta Malicka, Magdalena Biernacka, Jan Aleksander Beszłej, Jerzy Leszek
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Brain Sciences
Subjects:
Alzheimer’s disease
VEXAS
inflammation
dementia
neurodegeneration
cognitive decline
Online Access:https://www.mdpi.com/2076-3425/15/6/573
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