Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction
The renin-angiotensin system (RAS) is a hormone system that has been classically known as a blood pressure regulator but is becoming well recognized as a proinflammatory mediator. In many diverse tissues, RAS pathway elements are also produced intrinsically, making it possible for tissues to respond...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/581695 |
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| _version_ | 1849690539676401664 |
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| author | Toshihide Kurihara Yoko Ozawa Susumu Ishida Hideyuki Okano Kazuo Tsubota |
| author_facet | Toshihide Kurihara Yoko Ozawa Susumu Ishida Hideyuki Okano Kazuo Tsubota |
| author_sort | Toshihide Kurihara |
| collection | DOAJ |
| description | The renin-angiotensin system (RAS) is a hormone system that has been classically known as a blood pressure regulator but is becoming well recognized as a proinflammatory mediator. In many diverse tissues, RAS pathway elements are also produced intrinsically, making it possible for tissues to respond more dynamically to systemic or local cues. While RAS is important for controlling normal inflammatory responses, hyperactivation of the pathway can cause neural dysfunction by inducing accelerated degradation of some neuronal proteins such as synaptophysin and by activating pathological glial responses. Chronic inflammation and oxidative stress are risk factors for high incidence vision-threatening diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. In fact, increasing evidence suggests that RAS inhibition may actually prevent progression of various ocular diseases including uveitis, DR, AMD, and glaucoma. Therefore, RAS inhibition may be a promising therapeutic approach to fine-tune inflammatory responses and to prevent or treat certain ocular and neurodegenerative diseases. |
| format | Article |
| id | doaj-art-ec0a5c31e36a45698ffe8712fa43100b |
| institution | DOAJ |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-ec0a5c31e36a45698ffe8712fa43100b2025-08-20T03:21:17ZengWileyInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/581695581695Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural DysfunctionToshihide Kurihara0Yoko Ozawa1Susumu Ishida2Hideyuki Okano3Kazuo Tsubota4Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, JapanLaboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, JapanThe renin-angiotensin system (RAS) is a hormone system that has been classically known as a blood pressure regulator but is becoming well recognized as a proinflammatory mediator. In many diverse tissues, RAS pathway elements are also produced intrinsically, making it possible for tissues to respond more dynamically to systemic or local cues. While RAS is important for controlling normal inflammatory responses, hyperactivation of the pathway can cause neural dysfunction by inducing accelerated degradation of some neuronal proteins such as synaptophysin and by activating pathological glial responses. Chronic inflammation and oxidative stress are risk factors for high incidence vision-threatening diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. In fact, increasing evidence suggests that RAS inhibition may actually prevent progression of various ocular diseases including uveitis, DR, AMD, and glaucoma. Therefore, RAS inhibition may be a promising therapeutic approach to fine-tune inflammatory responses and to prevent or treat certain ocular and neurodegenerative diseases.http://dx.doi.org/10.1155/2012/581695 |
| spellingShingle | Toshihide Kurihara Yoko Ozawa Susumu Ishida Hideyuki Okano Kazuo Tsubota Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction International Journal of Inflammation |
| title | Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction |
| title_full | Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction |
| title_fullStr | Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction |
| title_full_unstemmed | Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction |
| title_short | Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction |
| title_sort | renin angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction |
| url | http://dx.doi.org/10.1155/2012/581695 |
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