Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic Aneurysm
Abdominal aortic aneurysm (AAA) is defined as a progressive segmental dilation of the abdominal aorta and is associated with high mortality. The characterized features of AAA indicate several underlying mechanisms of AAA formation and progression, including reactive oxygen species production, inflam...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2021/6615400 |
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| _version_ | 1850165243437645824 |
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| author | Mingqi Ouyang Mi Wang Bilian Yu |
| author_facet | Mingqi Ouyang Mi Wang Bilian Yu |
| author_sort | Mingqi Ouyang |
| collection | DOAJ |
| description | Abdominal aortic aneurysm (AAA) is defined as a progressive segmental dilation of the abdominal aorta and is associated with high mortality. The characterized features of AAA indicate several underlying mechanisms of AAA formation and progression, including reactive oxygen species production, inflammation, and atherosclerosis. Mitochondrial functions are critical for determining cell fate, and mitochondrial dynamics, especially selective mitochondrial autophagy, which is termed as mitophagy, has emerged as an important player in the pathogenesis of several cardiovascular diseases. The PARKIN/PARIS/PGC1α pathway is associated with AAA formation and has been proposed to play a role in mitochondrial dynamics mediated by the PINK/PARKIN pathway in the pathogenesis underlying AAA. This review is aimed at deepening our understanding of AAA formation and progression, which is vital for the development of potential medical therapies for AAA. |
| format | Article |
| id | doaj-art-ec07facd339b4d09b562ad36bd3a6a92 |
| institution | OA Journals |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-ec07facd339b4d09b562ad36bd3a6a922025-08-20T02:21:47ZengWileyCardiovascular Therapeutics1755-59141755-59222021-01-01202110.1155/2021/66154006615400Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic AneurysmMingqi Ouyang0Mi Wang1Bilian Yu2Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, ChinaAbdominal aortic aneurysm (AAA) is defined as a progressive segmental dilation of the abdominal aorta and is associated with high mortality. The characterized features of AAA indicate several underlying mechanisms of AAA formation and progression, including reactive oxygen species production, inflammation, and atherosclerosis. Mitochondrial functions are critical for determining cell fate, and mitochondrial dynamics, especially selective mitochondrial autophagy, which is termed as mitophagy, has emerged as an important player in the pathogenesis of several cardiovascular diseases. The PARKIN/PARIS/PGC1α pathway is associated with AAA formation and has been proposed to play a role in mitochondrial dynamics mediated by the PINK/PARKIN pathway in the pathogenesis underlying AAA. This review is aimed at deepening our understanding of AAA formation and progression, which is vital for the development of potential medical therapies for AAA.http://dx.doi.org/10.1155/2021/6615400 |
| spellingShingle | Mingqi Ouyang Mi Wang Bilian Yu Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic Aneurysm Cardiovascular Therapeutics |
| title | Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic Aneurysm |
| title_full | Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic Aneurysm |
| title_fullStr | Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic Aneurysm |
| title_full_unstemmed | Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic Aneurysm |
| title_short | Aberrant Mitochondrial Dynamics: An Emerging Pathogenic Driver of Abdominal Aortic Aneurysm |
| title_sort | aberrant mitochondrial dynamics an emerging pathogenic driver of abdominal aortic aneurysm |
| url | http://dx.doi.org/10.1155/2021/6615400 |
| work_keys_str_mv | AT mingqiouyang aberrantmitochondrialdynamicsanemergingpathogenicdriverofabdominalaorticaneurysm AT miwang aberrantmitochondrialdynamicsanemergingpathogenicdriverofabdominalaorticaneurysm AT bilianyu aberrantmitochondrialdynamicsanemergingpathogenicdriverofabdominalaorticaneurysm |