Classification of distinct tendinopathy subtypes for precision therapeutics
Abstract Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. Hence, this study attempted a classification of 126 diseased tendons into three distinct subtypes...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-53826-w |
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| author | Chenqi Tang Zetao Wang Yuanhao Xie Yang Fei Junchao Luo Canlong Wang Yue Ying Peiwen He Ruojing Yan Yangwu Chen Jiayun Huang Yiwen Xu Zicheng Wang Boon Chin Heng Hengzhi Liu Jianyou Li Zi Yin Haobo Wu Weishan Chen Hongwei Ouyang Xiao Chen Weiliang Shen |
| author_facet | Chenqi Tang Zetao Wang Yuanhao Xie Yang Fei Junchao Luo Canlong Wang Yue Ying Peiwen He Ruojing Yan Yangwu Chen Jiayun Huang Yiwen Xu Zicheng Wang Boon Chin Heng Hengzhi Liu Jianyou Li Zi Yin Haobo Wu Weishan Chen Hongwei Ouyang Xiao Chen Weiliang Shen |
| author_sort | Chenqi Tang |
| collection | DOAJ |
| description | Abstract Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. Hence, this study attempted a classification of 126 diseased tendons into three distinct subtypes with opposite pathogenic mechanisms based on transcriptomic and clinical features. The hypoxic atrophic subtype with white appearance (Hw) exhibits downregulated neovascularization pathways. The inflammatory proliferative subtype with white appearance (Iw) shows a moderate upregulation of inflammatory characteristics. The inflammatory proliferative subtype with red appearance (Ir) exhibits the highest levels of upregulated neovascularization and inflammatory pathways, along with severe joint dysfunction. We then established research models, including subtype-specific simulations in animal models and clinical data analysis. These revealed that glucocorticoid, a controversial commonly used drug, was only effective in treating the Ir subtype. Hence, the tendinopathy subtypes elucidated in this study have significant implications for developing precision treatment of tendinopathy. |
| format | Article |
| id | doaj-art-ec002aba2ed945c4a15395556ef601a2 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ec002aba2ed945c4a15395556ef601a22025-01-19T12:29:33ZengNature PortfolioNature Communications2041-17232024-11-0115111410.1038/s41467-024-53826-wClassification of distinct tendinopathy subtypes for precision therapeuticsChenqi Tang0Zetao Wang1Yuanhao Xie2Yang Fei3Junchao Luo4Canlong Wang5Yue Ying6Peiwen He7Ruojing Yan8Yangwu Chen9Jiayun Huang10Yiwen Xu11Zicheng Wang12Boon Chin Heng13Hengzhi Liu14Jianyou Li15Zi Yin16Haobo Wu17Weishan Chen18Hongwei Ouyang19Xiao Chen20Weiliang Shen21Department of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang UniversityDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of MedicineDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of StomatologyDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of MedicineInstitute of Sports Medicine, Zhejiang UniversityDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineDr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang UniversityInstitute of Sports Medicine, Zhejiang UniversityDepartment of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. Hence, this study attempted a classification of 126 diseased tendons into three distinct subtypes with opposite pathogenic mechanisms based on transcriptomic and clinical features. The hypoxic atrophic subtype with white appearance (Hw) exhibits downregulated neovascularization pathways. The inflammatory proliferative subtype with white appearance (Iw) shows a moderate upregulation of inflammatory characteristics. The inflammatory proliferative subtype with red appearance (Ir) exhibits the highest levels of upregulated neovascularization and inflammatory pathways, along with severe joint dysfunction. We then established research models, including subtype-specific simulations in animal models and clinical data analysis. These revealed that glucocorticoid, a controversial commonly used drug, was only effective in treating the Ir subtype. Hence, the tendinopathy subtypes elucidated in this study have significant implications for developing precision treatment of tendinopathy.https://doi.org/10.1038/s41467-024-53826-w |
| spellingShingle | Chenqi Tang Zetao Wang Yuanhao Xie Yang Fei Junchao Luo Canlong Wang Yue Ying Peiwen He Ruojing Yan Yangwu Chen Jiayun Huang Yiwen Xu Zicheng Wang Boon Chin Heng Hengzhi Liu Jianyou Li Zi Yin Haobo Wu Weishan Chen Hongwei Ouyang Xiao Chen Weiliang Shen Classification of distinct tendinopathy subtypes for precision therapeutics Nature Communications |
| title | Classification of distinct tendinopathy subtypes for precision therapeutics |
| title_full | Classification of distinct tendinopathy subtypes for precision therapeutics |
| title_fullStr | Classification of distinct tendinopathy subtypes for precision therapeutics |
| title_full_unstemmed | Classification of distinct tendinopathy subtypes for precision therapeutics |
| title_short | Classification of distinct tendinopathy subtypes for precision therapeutics |
| title_sort | classification of distinct tendinopathy subtypes for precision therapeutics |
| url | https://doi.org/10.1038/s41467-024-53826-w |
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