The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining
This study investigated the potential of phosphodiesterase type 5 (PDE-5) inhibitors, specifically tadalafil, in preventing the delayed cerebral ischemia (DCI) post-rupture of cerebral aneurysms. A total of 19 rabbits were used in this study, divided into different treatment groups, including nimodi...
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2024-08-01
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| author | Kwang Hyon Park Hyon-Jo Kwon Eun-Oh Jeong Hyeon-Song Koh Jeongwook Lim |
| author_facet | Kwang Hyon Park Hyon-Jo Kwon Eun-Oh Jeong Hyeon-Song Koh Jeongwook Lim |
| author_sort | Kwang Hyon Park |
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| description | This study investigated the potential of phosphodiesterase type 5 (PDE-5) inhibitors, specifically tadalafil, in preventing the delayed cerebral ischemia (DCI) post-rupture of cerebral aneurysms. A total of 19 rabbits were used in this study, divided into different treatment groups, including nimodipine alone, tadalafil alone, and a combination of nimodipine and tadalafil. Both nimodipine and tadalafil showed some impact on reducing endothelial apoptosis in the basilar arteries, although the effects were not statistically significant. Notably, the nimodipine group exhibited significantly lower levels of Bax in the small arterioles compared to the SAH group. These findings suggest that while tadalafil may not directly prevent endothelial cell death like nimodipine, its neuroprotective properties hint at its potential utility in DCI treatment. Further research involving a broader range of apoptosis-related proteins is recommended to enhance our understanding in this area. |
| format | Article |
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| institution | OA Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-08-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-ebff8e7c5a5645edbe657c39d6211abd2025-08-20T01:55:28ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-08-014699555956410.3390/cimb46090567The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical StainingKwang Hyon Park0Hyon-Jo Kwon1Eun-Oh Jeong2Hyeon-Song Koh3Jeongwook Lim4Department of Neurosurgery, Chungnam National University Sejong Hospital, Sejong 30099, Republic of KoreaDepartment of Neurosurgery, Chungnam National University School of Medicine, Daejeon 305764, Republic of KoreaDepartment of Neurosurgery, Chungnam National University Hospital, Daejeon 34134, Republic of KoreaDepartment of Neurosurgery, Chungnam National University School of Medicine, Daejeon 305764, Republic of KoreaDepartment of Neurosurgery, Chungnam National University Sejong Hospital, Sejong 30099, Republic of KoreaThis study investigated the potential of phosphodiesterase type 5 (PDE-5) inhibitors, specifically tadalafil, in preventing the delayed cerebral ischemia (DCI) post-rupture of cerebral aneurysms. A total of 19 rabbits were used in this study, divided into different treatment groups, including nimodipine alone, tadalafil alone, and a combination of nimodipine and tadalafil. Both nimodipine and tadalafil showed some impact on reducing endothelial apoptosis in the basilar arteries, although the effects were not statistically significant. Notably, the nimodipine group exhibited significantly lower levels of Bax in the small arterioles compared to the SAH group. These findings suggest that while tadalafil may not directly prevent endothelial cell death like nimodipine, its neuroprotective properties hint at its potential utility in DCI treatment. Further research involving a broader range of apoptosis-related proteins is recommended to enhance our understanding in this area.https://www.mdpi.com/1467-3045/46/9/567aneurysmsubarachnoid hemorrhagedelayed cerebral ischemianimodipinetadalafilendothelium |
| spellingShingle | Kwang Hyon Park Hyon-Jo Kwon Eun-Oh Jeong Hyeon-Song Koh Jeongwook Lim The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining Current Issues in Molecular Biology aneurysm subarachnoid hemorrhage delayed cerebral ischemia nimodipine tadalafil endothelium |
| title | The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining |
| title_full | The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining |
| title_fullStr | The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining |
| title_full_unstemmed | The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining |
| title_short | The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining |
| title_sort | potential therapeutic effects of tadalafil on the endothelium in a subarachnoid hemorrhage animal model insights from immunohistochemical staining |
| topic | aneurysm subarachnoid hemorrhage delayed cerebral ischemia nimodipine tadalafil endothelium |
| url | https://www.mdpi.com/1467-3045/46/9/567 |
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