Investigating the genomic background of calving-related traits in Canadian Jersey cattle
ABSTRACT: Traits related to calving have a significant impact on animal welfare and farm profitability in dairy production systems. Identifying genomic regions associated with calving traits could contribute to refining dairy cattle breeding programs and management practices in the dairy industry. T...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Dairy Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022030224010932 |
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| author | Pedro F.C. Aponte Paulo L.S. Carneiro Andre C. Araujo Victor B. Pedrosa Patrick R. Fotso-Kenmogne Delvan Alves Silva Filippo Miglior Flavio S. Schenkel Luiz F. Brito |
| author_facet | Pedro F.C. Aponte Paulo L.S. Carneiro Andre C. Araujo Victor B. Pedrosa Patrick R. Fotso-Kenmogne Delvan Alves Silva Filippo Miglior Flavio S. Schenkel Luiz F. Brito |
| author_sort | Pedro F.C. Aponte |
| collection | DOAJ |
| description | ABSTRACT: Traits related to calving have a significant impact on animal welfare and farm profitability in dairy production systems. Identifying genomic regions associated with calving traits could contribute to refining dairy cattle breeding programs and management practices in the dairy industry. Therefore, the primary objectives of this study were to estimate genetic parameters and perform GWAS and functional enrichment analyses for stillbirth, gestation length, calf size, and calving ease traits in North American Jersey cattle. A total of 40,503 animals with phenotypic records and 5,398 animals genotyped for 45,101 SNPs were included in the analyses. Genetic parameters were estimated based on animal models and Bayesian methods. The effects of SNPs were estimated using the single-step GBLUP method. The heritability (SE) estimates ranged from 0.01 (0.01) for stillbirths in heifers to 0.11 (0.01) for gestation length in cows. The genetic correlations ranged from −0.58 (0.11) between calving ease and stillbirths in heifers to 0.44 (0.14) between calving ease and calf size in cows. Calving ease showed the highest genetic correlation between heifers and cows, 0.8 (0.22) respectively. The candidate genes identified, including MTHFR, SERPINA5, IGFBP3, and ZRANB1, are involved in key biological processes and metabolic pathways related to the studied traits. Reducing environmental variation and identifying novel indicators of reproduction traits in the Jersey breed are needed given the low heritability estimates for most traits evaluated in this study. In conclusion, this study provides a characterization of the genetic background of calving-related traits in Jersey cattle. The estimates obtained can be used to improve or build selection indexes in Jersey cattle breeding programs in North America. |
| format | Article |
| id | doaj-art-ebf82648567b489ca45eb3a60c753cd1 |
| institution | OA Journals |
| issn | 0022-0302 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dairy Science |
| spelling | doaj-art-ebf82648567b489ca45eb3a60c753cd12025-08-20T01:54:11ZengElsevierJournal of Dairy Science0022-03022024-12-0110712111951121310.3168/jds.2024-24768Investigating the genomic background of calving-related traits in Canadian Jersey cattlePedro F.C. Aponte0Paulo L.S. Carneiro1Andre C. Araujo2Victor B. Pedrosa3Patrick R. Fotso-Kenmogne4Delvan Alves Silva5Filippo Miglior6Flavio S. Schenkel7Luiz F. Brito8Postgraduate Program in Animal Science, State University of Southwest Bahia, Itapetinga, BA 45700-000, BrazilDepartment of Biology, State University of Southwest Bahia, Jequié, BA 45205-490, Brazil; Corresponding authorsDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907Department of Animal Sciences, Purdue University, West Lafayette, IN 47907Postgraduate Program in Animal Science, State University of Southwest Bahia, Itapetinga, BA 45700-000, BrazilDepartment of Animal Science, Federal University of Viçosa, Viçosa, MG 36570-900, BrazilCenter for Genetic Improvement of Livestock (CGIL), Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada; Lactanet Canada, Guelph, ON, N1K 1E5, CanadaCenter for Genetic Improvement of Livestock (CGIL), Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907; Center for Genetic Improvement of Livestock (CGIL), Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada; Corresponding authorsABSTRACT: Traits related to calving have a significant impact on animal welfare and farm profitability in dairy production systems. Identifying genomic regions associated with calving traits could contribute to refining dairy cattle breeding programs and management practices in the dairy industry. Therefore, the primary objectives of this study were to estimate genetic parameters and perform GWAS and functional enrichment analyses for stillbirth, gestation length, calf size, and calving ease traits in North American Jersey cattle. A total of 40,503 animals with phenotypic records and 5,398 animals genotyped for 45,101 SNPs were included in the analyses. Genetic parameters were estimated based on animal models and Bayesian methods. The effects of SNPs were estimated using the single-step GBLUP method. The heritability (SE) estimates ranged from 0.01 (0.01) for stillbirths in heifers to 0.11 (0.01) for gestation length in cows. The genetic correlations ranged from −0.58 (0.11) between calving ease and stillbirths in heifers to 0.44 (0.14) between calving ease and calf size in cows. Calving ease showed the highest genetic correlation between heifers and cows, 0.8 (0.22) respectively. The candidate genes identified, including MTHFR, SERPINA5, IGFBP3, and ZRANB1, are involved in key biological processes and metabolic pathways related to the studied traits. Reducing environmental variation and identifying novel indicators of reproduction traits in the Jersey breed are needed given the low heritability estimates for most traits evaluated in this study. In conclusion, this study provides a characterization of the genetic background of calving-related traits in Jersey cattle. The estimates obtained can be used to improve or build selection indexes in Jersey cattle breeding programs in North America.http://www.sciencedirect.com/science/article/pii/S0022030224010932dairy cattlegenetic parametersGWASreproductionsingle-step GBLUP |
| spellingShingle | Pedro F.C. Aponte Paulo L.S. Carneiro Andre C. Araujo Victor B. Pedrosa Patrick R. Fotso-Kenmogne Delvan Alves Silva Filippo Miglior Flavio S. Schenkel Luiz F. Brito Investigating the genomic background of calving-related traits in Canadian Jersey cattle Journal of Dairy Science dairy cattle genetic parameters GWAS reproduction single-step GBLUP |
| title | Investigating the genomic background of calving-related traits in Canadian Jersey cattle |
| title_full | Investigating the genomic background of calving-related traits in Canadian Jersey cattle |
| title_fullStr | Investigating the genomic background of calving-related traits in Canadian Jersey cattle |
| title_full_unstemmed | Investigating the genomic background of calving-related traits in Canadian Jersey cattle |
| title_short | Investigating the genomic background of calving-related traits in Canadian Jersey cattle |
| title_sort | investigating the genomic background of calving related traits in canadian jersey cattle |
| topic | dairy cattle genetic parameters GWAS reproduction single-step GBLUP |
| url | http://www.sciencedirect.com/science/article/pii/S0022030224010932 |
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