METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD
A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/581 |
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| author | A. V. Baklykov A. A. Tumashov S. K. Kotovskaya E. N. Ulomsky G. L. Rusinov V. L. Rusinov G. A. Artem’ev D. S. Kopchuk V. N. Charushin |
| author_facet | A. V. Baklykov A. A. Tumashov S. K. Kotovskaya E. N. Ulomsky G. L. Rusinov V. L. Rusinov G. A. Artem’ev D. S. Kopchuk V. N. Charushin |
| author_sort | A. V. Baklykov |
| collection | DOAJ |
| description | A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18 (EKA, Sweden). The possibility of applying the developed procedure for the technological control of the third stage of the drug «Triazid» preparation was proved by the validation. |
| format | Article |
| id | doaj-art-ebf6dce434b24def95aa312d1ae2d3b3 |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-ebf6dce434b24def95aa312d1ae2d3b32025-08-20T03:39:28ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01027883581METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHODA. V. Baklykov0A. A. Tumashov1S. K. Kotovskaya2E. N. Ulomsky3G. L. Rusinov4V. L. Rusinov5G. A. Artem’ev6D. S. Kopchuk7V. N. Charushin8I.Ya. Postovsky Institute of organic synthesis UB of RASI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RASI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinA procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18 (EKA, Sweden). The possibility of applying the developed procedure for the technological control of the third stage of the drug «Triazid» preparation was proved by the validation.https://www.pharmjournal.ru/jour/article/view/5815-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l-argininytriazidehplcvalidation |
| spellingShingle | A. V. Baklykov A. A. Tumashov S. K. Kotovskaya E. N. Ulomsky G. L. Rusinov V. L. Rusinov G. A. Artem’ev D. S. Kopchuk V. N. Charushin METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD Разработка и регистрация лекарственных средств 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l-argininy triazide hplc validation |
| title | METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD |
| title_full | METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD |
| title_fullStr | METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD |
| title_full_unstemmed | METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD |
| title_short | METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD |
| title_sort | method of determination of 5 methyl 6 nitro 7 oxo 1 2 4 triazolo 1 5 i a i pirimidinide i l i argininy the active component of drug triazid by hplc method |
| topic | 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l-argininy triazide hplc validation |
| url | https://www.pharmjournal.ru/jour/article/view/581 |
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