Threonine in different phenotypes of chronic heart failure with preserved ejection fraction
Background — Chronic heart failure with preserved ejection fraction (CHFpEF) develops as a result of many diseases that lead to significant metabolic disorders. Given the heterogeneity of this group of patients, therapeutic options for this syndrome are extremely limited. In this regard, it seems pr...
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| Format: | Article |
| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2024-09-01
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| Series: | Russian Open Medical Journal |
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| Online Access: | https://romj.org/node/573 |
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| author | Maria F. Petruhnova Anastasia V. Krivova Vita Yu. Zektser Ekaterina O. Korobkova Tamerlan N. Edniev Anton A. Ageev Ksenia M. Shestakova Natalya E. Moskaleva Svetlana A. Appolonova Yury N. Belenkov Maria V. Kozhevnikova |
| author_facet | Maria F. Petruhnova Anastasia V. Krivova Vita Yu. Zektser Ekaterina O. Korobkova Tamerlan N. Edniev Anton A. Ageev Ksenia M. Shestakova Natalya E. Moskaleva Svetlana A. Appolonova Yury N. Belenkov Maria V. Kozhevnikova |
| author_sort | Maria F. Petruhnova |
| collection | DOAJ |
| description | Background — Chronic heart failure with preserved ejection fraction (CHFpEF) develops as a result of many diseases that lead to significant metabolic disorders. Given the heterogeneity of this group of patients, therapeutic options for this syndrome are extremely limited. In this regard, it seems promising to study the metabolomic profile in patients with CHFpEF to identify biomarkers, examine their roles in the pathogenesis of the syndrome, and search for potential targets for targeted therapy.
Objective — The study aimed at testing the correlation between the threonine level and the features of the clinical course of CHFpEF.
Methods — The study included a total of 154 patients: 82 with CHFpEF, 45 with hypertension and/or coronary artery disease (comparison group), and 27 healthy volunteers (control group). Threonine levels were assessed using high-performance liquid chromatography-mass spectrometry.
Results — The threonine concentration was significantly reduced in patients with CHFpEF (1) vs. comparison group (2) and control group (3): p<0.001; p1-3<0.001; p2-3=0.037). A reduction in the threonine level was characteristic for patients with diabetes mellitus vs. patients without it (p=0.029).
Conclusion — Given the importance of threonine in energy metabolism and significant changes in its level in various pathophysiological processes, it should be considered as an additional diagnostic and prognostic criterion for CHFpEF. Additional studies are needed to better understand the role of threonine in the pathophysiology of cardiovascular diseases. |
| format | Article |
| id | doaj-art-ebedf95c877143a3b39adb59e63e7444 |
| institution | DOAJ |
| issn | 2304-3415 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-ebedf95c877143a3b39adb59e63e74442025-08-20T03:07:38ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152024-09-01133e030410.15275/rusomj.2024.0304Threonine in different phenotypes of chronic heart failure with preserved ejection fractionMaria F. PetruhnovaAnastasia V. KrivovaVita Yu. ZektserEkaterina O. KorobkovaTamerlan N. EdnievAnton A. AgeevKsenia M. ShestakovaNatalya E. MoskalevaSvetlana A. AppolonovaYury N. BelenkovMaria V. KozhevnikovaBackground — Chronic heart failure with preserved ejection fraction (CHFpEF) develops as a result of many diseases that lead to significant metabolic disorders. Given the heterogeneity of this group of patients, therapeutic options for this syndrome are extremely limited. In this regard, it seems promising to study the metabolomic profile in patients with CHFpEF to identify biomarkers, examine their roles in the pathogenesis of the syndrome, and search for potential targets for targeted therapy. Objective — The study aimed at testing the correlation between the threonine level and the features of the clinical course of CHFpEF. Methods — The study included a total of 154 patients: 82 with CHFpEF, 45 with hypertension and/or coronary artery disease (comparison group), and 27 healthy volunteers (control group). Threonine levels were assessed using high-performance liquid chromatography-mass spectrometry. Results — The threonine concentration was significantly reduced in patients with CHFpEF (1) vs. comparison group (2) and control group (3): p<0.001; p1-3<0.001; p2-3=0.037). A reduction in the threonine level was characteristic for patients with diabetes mellitus vs. patients without it (p=0.029). Conclusion — Given the importance of threonine in energy metabolism and significant changes in its level in various pathophysiological processes, it should be considered as an additional diagnostic and prognostic criterion for CHFpEF. Additional studies are needed to better understand the role of threonine in the pathophysiology of cardiovascular diseases.https://romj.org/node/573arterial hypertensiondiabetes mellituschronic heart failurethreoninemetabolomics |
| spellingShingle | Maria F. Petruhnova Anastasia V. Krivova Vita Yu. Zektser Ekaterina O. Korobkova Tamerlan N. Edniev Anton A. Ageev Ksenia M. Shestakova Natalya E. Moskaleva Svetlana A. Appolonova Yury N. Belenkov Maria V. Kozhevnikova Threonine in different phenotypes of chronic heart failure with preserved ejection fraction Russian Open Medical Journal arterial hypertension diabetes mellitus chronic heart failure threonine metabolomics |
| title | Threonine in different phenotypes of chronic heart failure with preserved ejection fraction |
| title_full | Threonine in different phenotypes of chronic heart failure with preserved ejection fraction |
| title_fullStr | Threonine in different phenotypes of chronic heart failure with preserved ejection fraction |
| title_full_unstemmed | Threonine in different phenotypes of chronic heart failure with preserved ejection fraction |
| title_short | Threonine in different phenotypes of chronic heart failure with preserved ejection fraction |
| title_sort | threonine in different phenotypes of chronic heart failure with preserved ejection fraction |
| topic | arterial hypertension diabetes mellitus chronic heart failure threonine metabolomics |
| url | https://romj.org/node/573 |
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