Competing endogenous RNA networks in ovarian cancer
Epithelial ovarian cancer is responsible for the majority of ovarian malignancies, and its highly invasive nature and chemoresistant development have been major obstacles to treating patients with mainstream treatments. In recent decades, the significance of microRNAs (miRNAs), circular RNAs (circRN...
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| Format: | Article |
| Language: | English |
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IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
2025-01-01
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| Series: | EXCLI Journal : Experimental and Clinical Sciences |
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| Online Access: | https://www.excli.de/excli/article/view/7827 |
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| author | Roghaiyeh Derogar Fatemeh Nejadi Orang Mahdi Abdoli Shadbad |
| author_facet | Roghaiyeh Derogar Fatemeh Nejadi Orang Mahdi Abdoli Shadbad |
| author_sort | Roghaiyeh Derogar |
| collection | DOAJ |
| description | Epithelial ovarian cancer is responsible for the majority of ovarian malignancies, and its highly invasive nature and chemoresistant development have been major obstacles to treating patients with mainstream treatments. In recent decades, the significance of microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and competing endogenous RNAs (ceRNAs) has been highlighted in ovarian cancer development. This hidden language between these RNAs has led to the discovery of enormous regulatory networks in ovarian cancer cells that substantially affect gene expression. Aside from providing ample opportunities for targeted therapies, circRNA- and lncRNA-mediated ceRNA network components provide invaluable biomarkers. The current study provides a comprehensive and up-to-date review of the recent findings on the significance of these ceRNA networks in the hallmarks of ovarian cancer oncogenesis, treatment, diagnosis, and prognosis. Also, it provides the authorship with future perspectives in the era of single-cell RNA sequencing and personalized medicine.
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| format | Article |
| id | doaj-art-ebebe236a54c4f1baf26a898b62191b4 |
| institution | Kabale University |
| issn | 1611-2156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
| record_format | Article |
| series | EXCLI Journal : Experimental and Clinical Sciences |
| spelling | doaj-art-ebebe236a54c4f1baf26a898b62191b42025-08-20T14:56:04ZengIfADo - Leibniz Research Centre for Working Environment and Human Factors, DortmundEXCLI Journal : Experimental and Clinical Sciences1611-21562025-01-012410.17179/excli2024-7827Competing endogenous RNA networks in ovarian cancerRoghaiyeh Derogar0https://orcid.org/0009-0009-8926-1138Fatemeh Nejadi Orang1https://orcid.org/0009-0006-7381-0436Mahdi Abdoli Shadbad2https://orcid.org/0000-0003-4865-8779Fellowship in Gynecologic Oncology, Department of Gynecology, Faculty of Medical Sciences, Tabriz Medical Sciences, Islamic Azad University, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Daneshgah St., Tabriz, Iran. Phone No: +(98) 9036433290, E-mail: abdoli.med99@gmail.comEpithelial ovarian cancer is responsible for the majority of ovarian malignancies, and its highly invasive nature and chemoresistant development have been major obstacles to treating patients with mainstream treatments. In recent decades, the significance of microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and competing endogenous RNAs (ceRNAs) has been highlighted in ovarian cancer development. This hidden language between these RNAs has led to the discovery of enormous regulatory networks in ovarian cancer cells that substantially affect gene expression. Aside from providing ample opportunities for targeted therapies, circRNA- and lncRNA-mediated ceRNA network components provide invaluable biomarkers. The current study provides a comprehensive and up-to-date review of the recent findings on the significance of these ceRNA networks in the hallmarks of ovarian cancer oncogenesis, treatment, diagnosis, and prognosis. Also, it provides the authorship with future perspectives in the era of single-cell RNA sequencing and personalized medicine. https://www.excli.de/excli/article/view/7827ceRNA networkmicroRNAs (miRNAs)circular RNAcompeting endogenous RNAslong non-coding RNAovarian cancer |
| spellingShingle | Roghaiyeh Derogar Fatemeh Nejadi Orang Mahdi Abdoli Shadbad Competing endogenous RNA networks in ovarian cancer EXCLI Journal : Experimental and Clinical Sciences ceRNA network microRNAs (miRNAs) circular RNA competing endogenous RNAs long non-coding RNA ovarian cancer |
| title | Competing endogenous RNA networks in ovarian cancer |
| title_full | Competing endogenous RNA networks in ovarian cancer |
| title_fullStr | Competing endogenous RNA networks in ovarian cancer |
| title_full_unstemmed | Competing endogenous RNA networks in ovarian cancer |
| title_short | Competing endogenous RNA networks in ovarian cancer |
| title_sort | competing endogenous rna networks in ovarian cancer |
| topic | ceRNA network microRNAs (miRNAs) circular RNA competing endogenous RNAs long non-coding RNA ovarian cancer |
| url | https://www.excli.de/excli/article/view/7827 |
| work_keys_str_mv | AT roghaiyehderogar competingendogenousrnanetworksinovariancancer AT fatemehnejadiorang competingendogenousrnanetworksinovariancancer AT mahdiabdolishadbad competingendogenousrnanetworksinovariancancer |