The Role of Microglia in Diabetic Retinopathy
There is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy. There is also evidence that molecules produced as a result of hyperglycemia can activate microglia. However the exact contribution of microglia, the resident immune cells...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/705783 |
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| author | Jeffery G. Grigsby Sandra M. Cardona Cindy E. Pouw Alberto Muniz Andrew S. Mendiola Andrew T. C. Tsin Donald M. Allen Astrid E. Cardona |
| author_facet | Jeffery G. Grigsby Sandra M. Cardona Cindy E. Pouw Alberto Muniz Andrew S. Mendiola Andrew T. C. Tsin Donald M. Allen Astrid E. Cardona |
| author_sort | Jeffery G. Grigsby |
| collection | DOAJ |
| description | There is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy. There is also evidence that molecules produced as a result of hyperglycemia can activate microglia. However the exact contribution of microglia, the resident immune cells of the central nervous system, to retinal tissue damage during diabetes remains unclear. Current data suggest that dysregulated microglial responses are linked to their deleterious effects in several neurological diseases associated with chronic inflammation. As inflammatory cytokines and hyperglycemia disseminate through the diabetic retina, microglia can change to an activated state, increase in number, translocate through the retina, and themselves become the producers of inflammatory and apoptotic molecules or alternatively exert anti-inflammatory effects. In addition, microglial genetic variations may account for some of the individual differences commonly seen in patient’s susceptibility to diabetic retinopathy. |
| format | Article |
| id | doaj-art-ebe91c0bc35e4828a123a661bb000507 |
| institution | DOAJ |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ebe91c0bc35e4828a123a661bb0005072025-08-20T03:21:18ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/705783705783The Role of Microglia in Diabetic RetinopathyJeffery G. Grigsby0Sandra M. Cardona1Cindy E. Pouw2Alberto Muniz3Andrew S. Mendiola4Andrew T. C. Tsin5Donald M. Allen6Astrid E. Cardona7Vision Health Specialties, 4109 N. Midland Drive, Midland, TX 79707, USADepartment of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USACollege of Optometry, University of Houston, Houston, TX 77204, USADepartment of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USADepartment of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USADepartment of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USADepartment of Biology, The University of Texas of the Permian Basin, Odessa, TX 79762, USADepartment of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USAThere is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy. There is also evidence that molecules produced as a result of hyperglycemia can activate microglia. However the exact contribution of microglia, the resident immune cells of the central nervous system, to retinal tissue damage during diabetes remains unclear. Current data suggest that dysregulated microglial responses are linked to their deleterious effects in several neurological diseases associated with chronic inflammation. As inflammatory cytokines and hyperglycemia disseminate through the diabetic retina, microglia can change to an activated state, increase in number, translocate through the retina, and themselves become the producers of inflammatory and apoptotic molecules or alternatively exert anti-inflammatory effects. In addition, microglial genetic variations may account for some of the individual differences commonly seen in patient’s susceptibility to diabetic retinopathy.http://dx.doi.org/10.1155/2014/705783 |
| spellingShingle | Jeffery G. Grigsby Sandra M. Cardona Cindy E. Pouw Alberto Muniz Andrew S. Mendiola Andrew T. C. Tsin Donald M. Allen Astrid E. Cardona The Role of Microglia in Diabetic Retinopathy Journal of Ophthalmology |
| title | The Role of Microglia in Diabetic Retinopathy |
| title_full | The Role of Microglia in Diabetic Retinopathy |
| title_fullStr | The Role of Microglia in Diabetic Retinopathy |
| title_full_unstemmed | The Role of Microglia in Diabetic Retinopathy |
| title_short | The Role of Microglia in Diabetic Retinopathy |
| title_sort | role of microglia in diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2014/705783 |
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