Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration
Skeletal muscle is an important organ in the human body for maintaining overall strength and mobility. Skeletal muscle has the capability of self-regeneration, which can be achieved by utilizing specific energy pathways. Therefore, understanding the energy metabolism of skeletal muscle is essential...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1651553/full |
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| author | Jong Beom Jin Angelique Robinson Tori Soukup Ember Black André Abit André Abit Shane M. Hammer Anna Han Anna Han Edralin Lucas Yoo Kim Jiyoung Bae |
| author_facet | Jong Beom Jin Angelique Robinson Tori Soukup Ember Black André Abit André Abit Shane M. Hammer Anna Han Anna Han Edralin Lucas Yoo Kim Jiyoung Bae |
| author_sort | Jong Beom Jin |
| collection | DOAJ |
| description | Skeletal muscle is an important organ in the human body for maintaining overall strength and mobility. Skeletal muscle has the capability of self-regeneration, which can be achieved by utilizing specific energy pathways. Therefore, understanding the energy metabolism of skeletal muscle is essential to exploring its regenerative mechanisms. This review addresses the current progress in understanding the essential role of metabolic pathways in skeletal muscle function, regeneration, and muscle dysfunction as it relates to diseases such as type 2 diabetes mellitus (T2DM), obesity, and aging (sarcopenia). Furthermore, we explore the fundamental metabolisms of skeletal muscle while considering not only disease progression but also therapeutic strategies. Experimental models (in vivo and in vitro) and other signaling pathways are additionally discussed while proposing that the association between energy metabolism markers and metabolic diseases in skeletal muscle could provide innovative implications. Finally, the need for developing human-relevant models to study muscle regeneration is emphasized as most current findings are derived from in vivo and in vitro models. |
| format | Article |
| id | doaj-art-ebe7c02feb4e4a6ea7577565352ac14a |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-ebe7c02feb4e4a6ea7577565352ac14a2025-08-20T03:36:35ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-08-011310.3389/fcell.2025.16515531651553Metabolic and molecular regulation in skeletal muscle dysfunction and regenerationJong Beom Jin0Angelique Robinson1Tori Soukup2Ember Black3André Abit4André Abit5Shane M. Hammer6Anna Han7Anna Han8Edralin Lucas9Yoo Kim10Jiyoung Bae11Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesUniversity of Oklahoma College of Medicine, Oklahoma Health Science Center, Oklahoma City, OK, United StatesSchool of Kinesiology, Applied Health, and Recreation, Oklahoma State University, Stillwater, OK, United StatesDepartment of Food Science and Human Nutrition, Jeonbuk National University, Jeonju, Jeollabuk-do, Republic of KoreaK-Food Research Center, Jeonbuk National University, Jeonju, Jeollabuk-do, Republic of KoreaDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United StatesSkeletal muscle is an important organ in the human body for maintaining overall strength and mobility. Skeletal muscle has the capability of self-regeneration, which can be achieved by utilizing specific energy pathways. Therefore, understanding the energy metabolism of skeletal muscle is essential to exploring its regenerative mechanisms. This review addresses the current progress in understanding the essential role of metabolic pathways in skeletal muscle function, regeneration, and muscle dysfunction as it relates to diseases such as type 2 diabetes mellitus (T2DM), obesity, and aging (sarcopenia). Furthermore, we explore the fundamental metabolisms of skeletal muscle while considering not only disease progression but also therapeutic strategies. Experimental models (in vivo and in vitro) and other signaling pathways are additionally discussed while proposing that the association between energy metabolism markers and metabolic diseases in skeletal muscle could provide innovative implications. Finally, the need for developing human-relevant models to study muscle regeneration is emphasized as most current findings are derived from in vivo and in vitro models.https://www.frontiersin.org/articles/10.3389/fcell.2025.1651553/fullskeletal muscleregenerationmetabolismmechanismmetabolic diseases |
| spellingShingle | Jong Beom Jin Angelique Robinson Tori Soukup Ember Black André Abit André Abit Shane M. Hammer Anna Han Anna Han Edralin Lucas Yoo Kim Jiyoung Bae Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration Frontiers in Cell and Developmental Biology skeletal muscle regeneration metabolism mechanism metabolic diseases |
| title | Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration |
| title_full | Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration |
| title_fullStr | Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration |
| title_full_unstemmed | Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration |
| title_short | Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration |
| title_sort | metabolic and molecular regulation in skeletal muscle dysfunction and regeneration |
| topic | skeletal muscle regeneration metabolism mechanism metabolic diseases |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1651553/full |
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