Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

Summary: SARS-CoV-2 has caused the largest known coronavirus pandemic and is believed to have emerged from insectivorous bats. Little is known about the evolution of these viruses in their reservoir bat species. In this study, we investigate the SARS-CoV-2-host interaction using human and bat cells....

Full description

Saved in:
Bibliographic Details
Main Authors: Kaushal Baid, Sauhard Shrivastava, Jessica Luc, Daniel Richard, Jennifer A. Aguiar, Yoan Machado, Sophie-Marie Aicher, Kimberley C. Siwak, Emmanuelle V. LeBlanc, Zahed Khatooni, Kumari G. Lokugamage, Michelle N. Vu, Angelica Morgan, Arkadeb Bhuinya, Kim R. Chiok, Hai T. Nguyen, Hannah D. Stacey, Erin Scruten, Tracy Prysliak, Winfield Yim, Andrew G. McArthur, Matthew S. Miller, Heather L. Wilson, Terence Capellini, Paul A. Faure, Qiang Liu, Samira Mubareka, Vineet D. Menachery, Karen Mossman, Marcel A. Müller, Christian Drosten, Che C. Colpitts, Nolwenn Jouvenet, Christopher M. Overall, Andrew C. Doxey, Arinjay Banerjee
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007004
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary: SARS-CoV-2 has caused the largest known coronavirus pandemic and is believed to have emerged from insectivorous bats. Little is known about the evolution of these viruses in their reservoir bat species. In this study, we investigate the SARS-CoV-2-host interaction using human and bat cells. Bat cells mount a robust and early antiviral response but elicit a dampened proinflammatory response upon SARS-CoV-2 infection compared to human cells. Furthermore, an inactivating R685P mutation within the furin cleavage site (FCS) of the SARS-CoV-2 spike protein is naturally selected for in infected bat cells. Taken together, our data demonstrate that insectivorous Eptesicus fuscus bat cells have evolved a differential antiviral immune response against SARS-CoV-2 infection, likely contributing to their disease tolerance ability. Our study sheds light on the evolution of sarbecoviruses in bats and extends molecular evidence to data from field studies that have demonstrated that SARS-CoV-2-related viruses in wild-caught bats lack an intact FCS.
ISSN:2211-1247

Similar Items