Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties
<b>Background/Objectives</b>: The essential trace element zinc (Zn) has a pivotal role in wound healing and can show antibacterial activity, but its application in oral implant materials is underexplored. Customized healing abutments can modulate the peri-implant tissue health when appro...
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| Format: | Article |
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MDPI AG
2025-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/5/441 |
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| author | Wannes Van Holm Katleen Vandamme Jill Hadisurya Ferda Pamuk Naiera Zayed Merve Kübra Aktan Annabel Braem Andy Temmerman Wim Teughels |
| author_facet | Wannes Van Holm Katleen Vandamme Jill Hadisurya Ferda Pamuk Naiera Zayed Merve Kübra Aktan Annabel Braem Andy Temmerman Wim Teughels |
| author_sort | Wannes Van Holm |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: The essential trace element zinc (Zn) has a pivotal role in wound healing and can show antibacterial activity, but its application in oral implant materials is underexplored. Customized healing abutments can modulate the peri-implant tissue health when appropriate bioactive materials promoting mucosal healing are used. The present study investigated a novel Zn-containing polymer for its potential in soft-tissue engineering applications. <b>Methods</b>: Four traditional materials—titanium, glass ionomer, a composite, and the novel Zn-containing polymer—were tested in vitro for bacterial growth using a multispecies oral bacterial model compared to hydroxyapatite. The biocompatibility of the materials was also evaluated by evaluating the adhesion, proliferation, and cytotoxicity of human oral keratinocytes (HOK-18A) onto these materials, compared to tissue culture plastic. <b>Results</b>: The Zn-containing polymer exhibited a significantly lower biofilm formation compared to conventional materials as it was composed of less pathogenic bacteria. The Zn-containing material also demonstrated a superior biocompatibility towards HOK-18A, approximating the adhesion and proliferation of the keratinocytes to optimal tissue culture conditions. Moreover, these properties did not seem to degrade and were maintained over a period of 31 days. The cytotoxicity assessment revealed no significant reduction in metabolic activity for any material. <b>Conclusions</b>: This study highlights the potential of the novel Zn-containing polymer in soft-tissue engineering, owing to its antimicrobial and biocompatible assets. These properties, combined with the ease of chairside modeling, position the material as a promising alternative for creating customized healing abutments. Further research is needed to explore its mechanism of wound healing modulation and its clinical performance. |
| format | Article |
| id | doaj-art-ebe4544add0a452f98073cb09673a7f0 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-ebe4544add0a452f98073cb09673a7f02025-08-20T01:57:04ZengMDPI AGAntibiotics2079-63822025-04-0114544110.3390/antibiotics14050441Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative PropertiesWannes Van Holm0Katleen Vandamme1Jill Hadisurya2Ferda Pamuk3Naiera Zayed4Merve Kübra Aktan5Annabel Braem6Andy Temmerman7Wim Teughels8KU Leuven, Department of Oral Health Sciences, Research Unit Periodontology and Oral Microbiology (P&OM), B-3000 Leuven, BelgiumKU Leuven, Department of Oral Health Sciences, Research Unit Periodontology and Oral Microbiology (P&OM), B-3000 Leuven, BelgiumKU Leuven, Department of Oral Health Sciences, Research Unit Periodontology and Oral Microbiology (P&OM), B-3000 Leuven, BelgiumKU Leuven, Department of Oral Health Sciences, Research Unit Periodontology and Oral Microbiology (P&OM), B-3000 Leuven, BelgiumKU Leuven, Department of Oral Health Sciences, Research Unit Periodontology and Oral Microbiology (P&OM), B-3000 Leuven, BelgiumKU Leuven, Department of Materials Engineering, Biomaterials and Tissue Engineering Research Group, B-3001 Leuven, BelgiumKU Leuven, Department of Materials Engineering, Biomaterials and Tissue Engineering Research Group, B-3001 Leuven, BelgiumKU Leuven, Department of Oral Health Sciences, Research Unit Periodontology and Oral Microbiology (P&OM), B-3000 Leuven, BelgiumKU Leuven, Department of Oral Health Sciences, Research Unit Periodontology and Oral Microbiology (P&OM), B-3000 Leuven, Belgium<b>Background/Objectives</b>: The essential trace element zinc (Zn) has a pivotal role in wound healing and can show antibacterial activity, but its application in oral implant materials is underexplored. Customized healing abutments can modulate the peri-implant tissue health when appropriate bioactive materials promoting mucosal healing are used. The present study investigated a novel Zn-containing polymer for its potential in soft-tissue engineering applications. <b>Methods</b>: Four traditional materials—titanium, glass ionomer, a composite, and the novel Zn-containing polymer—were tested in vitro for bacterial growth using a multispecies oral bacterial model compared to hydroxyapatite. The biocompatibility of the materials was also evaluated by evaluating the adhesion, proliferation, and cytotoxicity of human oral keratinocytes (HOK-18A) onto these materials, compared to tissue culture plastic. <b>Results</b>: The Zn-containing polymer exhibited a significantly lower biofilm formation compared to conventional materials as it was composed of less pathogenic bacteria. The Zn-containing material also demonstrated a superior biocompatibility towards HOK-18A, approximating the adhesion and proliferation of the keratinocytes to optimal tissue culture conditions. Moreover, these properties did not seem to degrade and were maintained over a period of 31 days. The cytotoxicity assessment revealed no significant reduction in metabolic activity for any material. <b>Conclusions</b>: This study highlights the potential of the novel Zn-containing polymer in soft-tissue engineering, owing to its antimicrobial and biocompatible assets. These properties, combined with the ease of chairside modeling, position the material as a promising alternative for creating customized healing abutments. Further research is needed to explore its mechanism of wound healing modulation and its clinical performance.https://www.mdpi.com/2079-6382/14/5/441peri-implantitissoft-tissue engineeringzincwound healingbiocompatibilityhealing abutment |
| spellingShingle | Wannes Van Holm Katleen Vandamme Jill Hadisurya Ferda Pamuk Naiera Zayed Merve Kübra Aktan Annabel Braem Andy Temmerman Wim Teughels Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties Antibiotics peri-implantitis soft-tissue engineering zinc wound healing biocompatibility healing abutment |
| title | Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties |
| title_full | Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties |
| title_fullStr | Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties |
| title_full_unstemmed | Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties |
| title_short | Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties |
| title_sort | thermoplastic zinc infused polymer for chairside socket seal abutments enhances antimicrobial and tissue integrative properties |
| topic | peri-implantitis soft-tissue engineering zinc wound healing biocompatibility healing abutment |
| url | https://www.mdpi.com/2079-6382/14/5/441 |
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