Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19

Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19

Abstract Background Although several genetic biomarkers have been reported in the tocilizumab (TCZ) response in rheumatoid arthritis, no studies have addressed the pharmacogenomics effect of TCZ in COVID-19. Methods In this prospective longitudinal study, 95 individuals with severe COVID-19 were sel...

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Main Authors: Nastaran Injinari, Samira Asadollahi, Fateme Sefid, Maedeh Arshadi, Saeedeh Sadat Hosseini, Hamed Ghoshouni, Fatemeh Soltani, Nasim Namiranian, Mohammad Hasan Sheikhha, Fatemeh Aghaeimeybodi
Format: Article
Language:English
Published: BMC 2024-10-01
Series:BMC Infectious Diseases
Subjects:
Tocilizumab
COVID-19
Polymorphism
FCGR2A
IL-6 receptor
Online Access:https://doi.org/10.1186/s12879-024-10073-0
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