Clinical and pharmacological monitoring of drug safety in pediatrics
The 95 cases of adverse drug reactions in children were registered in the Centre of Drug Safety Monitoring of Irkutsk Region from 2009 to 2015. In 21.4 % of cases, the coexistent affections developed. Children were allergic three times more often than adults. In 14.7 % of cases severe allergic react...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2016-05-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/221 |
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| author | N. V. Verlan E. O. Kochkina A. V. Kochkin L. V. Okhremchuk A. V. Popadyuk |
| author_facet | N. V. Verlan E. O. Kochkina A. V. Kochkin L. V. Okhremchuk A. V. Popadyuk |
| author_sort | N. V. Verlan |
| collection | DOAJ |
| description | The 95 cases of adverse drug reactions in children were registered in the Centre of Drug Safety Monitoring of Irkutsk Region from 2009 to 2015. In 21.4 % of cases, the coexistent affections developed. Children were allergic three times more often than adults. In 14.7 % of cases severe allergic reactions were registered. Most often allergies occurred after taking immunotropic (62.2 %), antimicrobial (16.2 %) and nonsteroidal anti-inflammatory drugs (10.8 %). 10.5 % of cases concerned inefficient drug use in children under 3 years; and 36.8 % of cases concerned children aged 3 to 18 years. The following risk factors of inefficient antibiotic therapy in children with urinary system infections were determined: the duration of the disease up to 5 years, isolation of two or more infectious agents and concomitant infections of upper and lower urinary tract. Adverse drug reaction occurred more often when more than three drugs were prescribed at the same time. Such cases were generally registered in patients with infectious diseases and epilepsy. Risk of adverse reaction increased with the off-label drug use. Introduction of monitoring methods and prediction algorithms allowing to reveal with high probability and to prevent adverse drug reactions in children improved efficiency and quality of pharmacotherapy |
| format | Article |
| id | doaj-art-ebdb44e8a9534f3490f6a497b2fee786 |
| institution | Kabale University |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2016-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-ebdb44e8a9534f3490f6a497b2fee7862025-08-20T03:56:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962016-05-0113(1)293210.12737/21590221Clinical and pharmacological monitoring of drug safety in pediatricsN. V. Verlan0E. O. Kochkina1A. V. Kochkin2L. V. Okhremchuk3A. V. Popadyuk4Center of Quality Control and Drug Certification of Irkutsk RegionCenter of Quality Control and Drug Certification of Irkutsk RegionIrkutsk State Medical Academy of Continuing EducationIrkutsk State Medical Academy of Continuing EducationCenter of Quality Control and Drug Certification of Irkutsk RegionThe 95 cases of adverse drug reactions in children were registered in the Centre of Drug Safety Monitoring of Irkutsk Region from 2009 to 2015. In 21.4 % of cases, the coexistent affections developed. Children were allergic three times more often than adults. In 14.7 % of cases severe allergic reactions were registered. Most often allergies occurred after taking immunotropic (62.2 %), antimicrobial (16.2 %) and nonsteroidal anti-inflammatory drugs (10.8 %). 10.5 % of cases concerned inefficient drug use in children under 3 years; and 36.8 % of cases concerned children aged 3 to 18 years. The following risk factors of inefficient antibiotic therapy in children with urinary system infections were determined: the duration of the disease up to 5 years, isolation of two or more infectious agents and concomitant infections of upper and lower urinary tract. Adverse drug reaction occurred more often when more than three drugs were prescribed at the same time. Such cases were generally registered in patients with infectious diseases and epilepsy. Risk of adverse reaction increased with the off-label drug use. Introduction of monitoring methods and prediction algorithms allowing to reveal with high probability and to prevent adverse drug reactions in children improved efficiency and quality of pharmacotherapyhttps://www.actabiomedica.ru/jour/article/view/221childrendrug reactiondrugssafety monitoringadverse drug reaction |
| spellingShingle | N. V. Verlan E. O. Kochkina A. V. Kochkin L. V. Okhremchuk A. V. Popadyuk Clinical and pharmacological monitoring of drug safety in pediatrics Acta Biomedica Scientifica children drug reaction drugs safety monitoring adverse drug reaction |
| title | Clinical and pharmacological monitoring of drug safety in pediatrics |
| title_full | Clinical and pharmacological monitoring of drug safety in pediatrics |
| title_fullStr | Clinical and pharmacological monitoring of drug safety in pediatrics |
| title_full_unstemmed | Clinical and pharmacological monitoring of drug safety in pediatrics |
| title_short | Clinical and pharmacological monitoring of drug safety in pediatrics |
| title_sort | clinical and pharmacological monitoring of drug safety in pediatrics |
| topic | children drug reaction drugs safety monitoring adverse drug reaction |
| url | https://www.actabiomedica.ru/jour/article/view/221 |
| work_keys_str_mv | AT nvverlan clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT eokochkina clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT avkochkin clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT lvokhremchuk clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT avpopadyuk clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics |