COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient
Since the global coronavirus disease 2019 (COVID-19) pandemic began, findings indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might induce autoimmune disorders. Thrombotic thrombocytopenic purpura (TTP) is a devastating disease if not emergently treated. It presents with s...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2022/2934171 |
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| author | Mariana Codevila Buere Pereira Bruna Ruschel Bruna Schneider Vitor Salomão Gonçalves Melo de Melgar Tatiana Helena Rech |
| author_facet | Mariana Codevila Buere Pereira Bruna Ruschel Bruna Schneider Vitor Salomão Gonçalves Melo de Melgar Tatiana Helena Rech |
| author_sort | Mariana Codevila Buere Pereira |
| collection | DOAJ |
| description | Since the global coronavirus disease 2019 (COVID-19) pandemic began, findings indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might induce autoimmune disorders. Thrombotic thrombocytopenic purpura (TTP) is a devastating disease if not emergently treated. It presents with severe thrombocytopenia, microangiopathic hemolytic anemia, and neurologic findings with or without renal insufficiency. The antibody-mediated reduced activity of the disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) induces the accumulation of ultrahigh-molecular-weight multimers of von Willebrand factor, leading to platelet aggregation and thrombosis. TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. We report a case of a healthy young patient presenting with the classic TTP pentad a few days after a diagnosis of COVID-19 confirmed by a positive SARS-CoV-2 RT-PCR test. The patient was initially treated with high-dose methylprednisolone and fresh frozen plasma until she was transferred to a tertiary care facility and plasma exchange was available. She evolved with a malignant ischemic vascular accident and was declared brain-dead 24 hours after the first plasma exchange section. |
| format | Article |
| id | doaj-art-ebd97f48b9bb497eb6b8030fcacd58e9 |
| institution | Kabale University |
| issn | 2090-6439 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-ebd97f48b9bb497eb6b8030fcacd58e92025-02-03T05:57:27ZengWileyCase Reports in Critical Care2090-64392022-01-01202210.1155/2022/2934171COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young PatientMariana Codevila Buere Pereira0Bruna Ruschel1Bruna Schneider2Vitor Salomão Gonçalves Melo de Melgar3Tatiana Helena Rech4School of MedicineSchool of MedicineIntensive Care UnitNeurology DivisionSchool of MedicineSince the global coronavirus disease 2019 (COVID-19) pandemic began, findings indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might induce autoimmune disorders. Thrombotic thrombocytopenic purpura (TTP) is a devastating disease if not emergently treated. It presents with severe thrombocytopenia, microangiopathic hemolytic anemia, and neurologic findings with or without renal insufficiency. The antibody-mediated reduced activity of the disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) induces the accumulation of ultrahigh-molecular-weight multimers of von Willebrand factor, leading to platelet aggregation and thrombosis. TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. We report a case of a healthy young patient presenting with the classic TTP pentad a few days after a diagnosis of COVID-19 confirmed by a positive SARS-CoV-2 RT-PCR test. The patient was initially treated with high-dose methylprednisolone and fresh frozen plasma until she was transferred to a tertiary care facility and plasma exchange was available. She evolved with a malignant ischemic vascular accident and was declared brain-dead 24 hours after the first plasma exchange section.http://dx.doi.org/10.1155/2022/2934171 |
| spellingShingle | Mariana Codevila Buere Pereira Bruna Ruschel Bruna Schneider Vitor Salomão Gonçalves Melo de Melgar Tatiana Helena Rech COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient Case Reports in Critical Care |
| title | COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient |
| title_full | COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient |
| title_fullStr | COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient |
| title_full_unstemmed | COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient |
| title_short | COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient |
| title_sort | covid 19 induced fatal thrombotic thrombocytopenic purpura in a healthy young patient |
| url | http://dx.doi.org/10.1155/2022/2934171 |
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