Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.

Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.

The lack of dystrophin in Duchenne muscular dystrophy (DMD) compromises the integrity and function of muscle fibers. Skeletal muscles, except the diaphragm, do not undergo progressive degeneration in adult mdx mice due to compensatory mechanisms, including structural protein upregulation. New mouse...

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Bibliographic Details
Main Authors: Antoine Boulanger Piette, Dounia Hamoudi, Laetitia Marcadet, Frédérique Kyomi Labelle, Rares Ovidiu David, Sabrina Bossé, Anteneh Argaw, Jérôme Frenette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198408/1/pone.0198408.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T135746Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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