Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis
Abstract Fibromyalgia (FM) and ankylosing spondylitis (AS) are both rheumatic diseases characterized by significant musculoskeletal pain. In this study, we investigated the differences of the resting-state network (RSN) connectivity and gray matter volume (GMV) between FM, AS and healthy controls (H...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-79246-w |
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| author | Dong Liu Yanli Zhang Jiaoshi Zhao Budian Liu Churong Lin Mingcan Yang Jieruo Gu Ou Jin |
| author_facet | Dong Liu Yanli Zhang Jiaoshi Zhao Budian Liu Churong Lin Mingcan Yang Jieruo Gu Ou Jin |
| author_sort | Dong Liu |
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| description | Abstract Fibromyalgia (FM) and ankylosing spondylitis (AS) are both rheumatic diseases characterized by significant musculoskeletal pain. In this study, we investigated the differences of the resting-state network (RSN) connectivity and gray matter volume (GMV) between FM, AS and healthy controls (HCs). We recruited 38 FM patients, 82 AS patients and 61 HCs in this study. All the participants underwent resting-state functional MRI (rs-fMRI) scans in a GE 3.0T MR system. Independent component analysis (ICA) was conducted on the rs-fMRI data, and group differences of the rsFC between different resting-state networks were calculated using dual regression. We also conducted voxel-based morphometry (VBM) analysis to investigate the differences of the GMV in FM, AS and HCs. The rsFC between the dorsal default mode network (DDMN) and the body of left caudate nucleus was significantly decreased in FM patients in comparison to AS patients (87 voxels, p = 0.025). VBM analysis showed that the GMV of the left posterior lobe of cerebellum was significantly increased in FM patients compared with AS patients (88 voxels, p = 0.036). Neither ICA nor VBM analysis revealed significant differences of RSN connectivity or GMV between FM patients and HCs. The altered rsFC between DMN and the caudate nucleus suggested an aberrant cortico-striato-thalamo-cortical circuit in FM patients, indicating aberrant reward processing, with potential association with mood, motivation and cognitive functions. The increased GMV in the left posterior lobe of cerebellum indicated the participation of cerebellum in the abnormal pain processing in FM patients. |
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| spelling | doaj-art-ebd40e7c4f474f2bb2fa9b17173aab872025-08-20T02:20:41ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-79246-wAlterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitisDong Liu0Yanli Zhang1Jiaoshi Zhao2Budian Liu3Churong Lin4Mingcan Yang5Jieruo Gu6Ou Jin7Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Radiology, the Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen UniversityAbstract Fibromyalgia (FM) and ankylosing spondylitis (AS) are both rheumatic diseases characterized by significant musculoskeletal pain. In this study, we investigated the differences of the resting-state network (RSN) connectivity and gray matter volume (GMV) between FM, AS and healthy controls (HCs). We recruited 38 FM patients, 82 AS patients and 61 HCs in this study. All the participants underwent resting-state functional MRI (rs-fMRI) scans in a GE 3.0T MR system. Independent component analysis (ICA) was conducted on the rs-fMRI data, and group differences of the rsFC between different resting-state networks were calculated using dual regression. We also conducted voxel-based morphometry (VBM) analysis to investigate the differences of the GMV in FM, AS and HCs. The rsFC between the dorsal default mode network (DDMN) and the body of left caudate nucleus was significantly decreased in FM patients in comparison to AS patients (87 voxels, p = 0.025). VBM analysis showed that the GMV of the left posterior lobe of cerebellum was significantly increased in FM patients compared with AS patients (88 voxels, p = 0.036). Neither ICA nor VBM analysis revealed significant differences of RSN connectivity or GMV between FM patients and HCs. The altered rsFC between DMN and the caudate nucleus suggested an aberrant cortico-striato-thalamo-cortical circuit in FM patients, indicating aberrant reward processing, with potential association with mood, motivation and cognitive functions. The increased GMV in the left posterior lobe of cerebellum indicated the participation of cerebellum in the abnormal pain processing in FM patients.https://doi.org/10.1038/s41598-024-79246-wFibromyalgiaAnkylosing spondylitisFunctional connectivityFunctional MRIIndependent component analysis |
| spellingShingle | Dong Liu Yanli Zhang Jiaoshi Zhao Budian Liu Churong Lin Mingcan Yang Jieruo Gu Ou Jin Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis Scientific Reports Fibromyalgia Ankylosing spondylitis Functional connectivity Functional MRI Independent component analysis |
| title | Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis |
| title_full | Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis |
| title_fullStr | Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis |
| title_full_unstemmed | Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis |
| title_short | Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis |
| title_sort | alterations of the resting state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis |
| topic | Fibromyalgia Ankylosing spondylitis Functional connectivity Functional MRI Independent component analysis |
| url | https://doi.org/10.1038/s41598-024-79246-w |
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