A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary
Viscosity measurement is crucial in medical diagnostics, pharmaceuticals, and analytical chemistry, where samples are frequently in small volumes and measurements are supposed to be conducted in a short time with convenient approaches. In this study, we propose a viscosity measurement approach based...
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Elsevier
2024-12-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180424000746 |
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| author | Shaohong Qu Songli Hu Ting Li Chaomin Wu Yuexiu Chen Linqian Zhao Lihang Zhu Jianjun Wu Zhifeng Tang Peifang Dong Fengjiang Zhang |
| author_facet | Shaohong Qu Songli Hu Ting Li Chaomin Wu Yuexiu Chen Linqian Zhao Lihang Zhu Jianjun Wu Zhifeng Tang Peifang Dong Fengjiang Zhang |
| author_sort | Shaohong Qu |
| collection | DOAJ |
| description | Viscosity measurement is crucial in medical diagnostics, pharmaceuticals, and analytical chemistry, where samples are frequently in small volumes and measurements are supposed to be conducted in a short time with convenient approaches. In this study, we propose a viscosity measurement approach based on longitudinal guided waves with a dominant in-plane displacement. The viscosity is determined using the attenuation of longitudinal guided waves in a liquid-filled capillary. The use of guided waves accelerates the measurement while the application of a capillary reduces the sample volume. Additionally, the approach is nondestructive and repeatable since the liquid sample is injected into the capillary instead of immersing the probe into the liquid; the sample is located in a relatively closed tube, reducing the interferences of outside factors. In our propomsed method, the sample volume is only 176.6 μL and the measurement time of one sample is only 5.6 ms. The effectiveness and practicability of the proposed approach is confirmed by measuring silicon oils with viscosities from 9.01 mPa·s to 532 mPa·s and a limit of detection (LOD) of 0.97 mPa·s. The minimum error is about 5 % at 442 mPa·s and the maximum error is about 18 % at 9.01 mPa·s Besides, the approach was employed for detection of viscosity in artificial tear samples, which indicated that satisfactory applicability was achieved. This work not only demonstrates the judicious design of a rapid and non-immersed method for viscosity measurement, but also a promising scheme for point-of-care analysis of tear viscosity, thus offering great potential for at-home diagnosis and personalized healthcare of various ocular diseases. |
| format | Article |
| id | doaj-art-ebd19bad038e4e5ea0a07c6a97328ce4 |
| institution | OA Journals |
| issn | 2214-1804 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj-art-ebd19bad038e4e5ea0a07c6a97328ce42025-08-20T02:30:35ZengElsevierSensing and Bio-Sensing Research2214-18042024-12-014610069210.1016/j.sbsr.2024.100692A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillaryShaohong Qu0Songli Hu1Ting Li2Chaomin Wu3Yuexiu Chen4Linqian Zhao5Lihang Zhu6Jianjun Wu7Zhifeng Tang8Peifang Dong9Fengjiang Zhang10Nursing Department of Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, ChinaDepartment of Anesthesiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, Zhejiang, ChinaDepartment of Anesthesiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, Zhejiang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China; Department of Anesthesiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, Zhejiang, ChinaDepartment of Clinical Engineering, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, ChinaResearch Center of Material and High-End Equipment, Huzhou Institute of Zhejiang University, Huzhou 313000, Zhejiang, China; College of Control Science and Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaInstitute of Advanced Digital Technologies and Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaNursing Department of Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China; Corresponding authors.Department of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China; Corresponding authors.Viscosity measurement is crucial in medical diagnostics, pharmaceuticals, and analytical chemistry, where samples are frequently in small volumes and measurements are supposed to be conducted in a short time with convenient approaches. In this study, we propose a viscosity measurement approach based on longitudinal guided waves with a dominant in-plane displacement. The viscosity is determined using the attenuation of longitudinal guided waves in a liquid-filled capillary. The use of guided waves accelerates the measurement while the application of a capillary reduces the sample volume. Additionally, the approach is nondestructive and repeatable since the liquid sample is injected into the capillary instead of immersing the probe into the liquid; the sample is located in a relatively closed tube, reducing the interferences of outside factors. In our propomsed method, the sample volume is only 176.6 μL and the measurement time of one sample is only 5.6 ms. The effectiveness and practicability of the proposed approach is confirmed by measuring silicon oils with viscosities from 9.01 mPa·s to 532 mPa·s and a limit of detection (LOD) of 0.97 mPa·s. The minimum error is about 5 % at 442 mPa·s and the maximum error is about 18 % at 9.01 mPa·s Besides, the approach was employed for detection of viscosity in artificial tear samples, which indicated that satisfactory applicability was achieved. This work not only demonstrates the judicious design of a rapid and non-immersed method for viscosity measurement, but also a promising scheme for point-of-care analysis of tear viscosity, thus offering great potential for at-home diagnosis and personalized healthcare of various ocular diseases.http://www.sciencedirect.com/science/article/pii/S2214180424000746Tear viscosity analysisRapid viscosity measurementOcular disease diagnosticsUltrasonic guided wavesTiny-volume analysisMagnetostrictive effect |
| spellingShingle | Shaohong Qu Songli Hu Ting Li Chaomin Wu Yuexiu Chen Linqian Zhao Lihang Zhu Jianjun Wu Zhifeng Tang Peifang Dong Fengjiang Zhang A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary Sensing and Bio-Sensing Research Tear viscosity analysis Rapid viscosity measurement Ocular disease diagnostics Ultrasonic guided waves Tiny-volume analysis Magnetostrictive effect |
| title | A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary |
| title_full | A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary |
| title_fullStr | A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary |
| title_full_unstemmed | A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary |
| title_short | A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary |
| title_sort | rapid and non immersed method of viscosity measurement with small volume samples based on longitudinal guided waves in capillary |
| topic | Tear viscosity analysis Rapid viscosity measurement Ocular disease diagnostics Ultrasonic guided waves Tiny-volume analysis Magnetostrictive effect |
| url | http://www.sciencedirect.com/science/article/pii/S2214180424000746 |
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