Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study
Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2023/7000858 |
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| author | Chommanart Thongkittidilok Maki Hirata Qingyi Lin Nanaka Torigoe Bin Liu Yoko Sato Megumi Nagahara Fuminori Tanihara Takeshige Otoi |
| author_facet | Chommanart Thongkittidilok Maki Hirata Qingyi Lin Nanaka Torigoe Bin Liu Yoko Sato Megumi Nagahara Fuminori Tanihara Takeshige Otoi |
| author_sort | Chommanart Thongkittidilok |
| collection | DOAJ |
| description | Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino acid changes in TP53 sequences are related to tumorigenesis. The pig without tumours had a wild-type TP53 sequence and a 1-bp deletion in the TP53 sequence that resulted in a premature stop codon. In contrast, the pig with nephroblastoma had 6- and 7-bp deletions in the TP53 sequence, resulting in the absence of two amino acids and a premature stop codon, respectively. Our results indicated that TP53 mutations with truncated amino acids may be related to tumour formation. |
| format | Article |
| id | doaj-art-ebc72171b60d4c0086d62487ac252ce6 |
| institution | OA Journals |
| issn | 2042-0048 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-ebc72171b60d4c0086d62487ac252ce62025-08-20T02:22:20ZengWileyVeterinary Medicine International2042-00482023-01-01202310.1155/2023/7000858Mosaic TP53 Mutation on Tumour Development in Pigs: A Case StudyChommanart Thongkittidilok0Maki Hirata1Qingyi Lin2Nanaka Torigoe3Bin Liu4Yoko Sato5Megumi Nagahara6Fuminori Tanihara7Takeshige Otoi8Bio-Innovation Research CenterBio-Innovation Research CenterBio-Innovation Research CenterBio-Innovation Research CenterBio-Innovation Research CenterDepartment of Veterinary ScienceBio-Innovation Research CenterFaculty of Bioscience and BioindustryBio-Innovation Research CenterPigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino acid changes in TP53 sequences are related to tumorigenesis. The pig without tumours had a wild-type TP53 sequence and a 1-bp deletion in the TP53 sequence that resulted in a premature stop codon. In contrast, the pig with nephroblastoma had 6- and 7-bp deletions in the TP53 sequence, resulting in the absence of two amino acids and a premature stop codon, respectively. Our results indicated that TP53 mutations with truncated amino acids may be related to tumour formation.http://dx.doi.org/10.1155/2023/7000858 |
| spellingShingle | Chommanart Thongkittidilok Maki Hirata Qingyi Lin Nanaka Torigoe Bin Liu Yoko Sato Megumi Nagahara Fuminori Tanihara Takeshige Otoi Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study Veterinary Medicine International |
| title | Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study |
| title_full | Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study |
| title_fullStr | Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study |
| title_full_unstemmed | Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study |
| title_short | Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study |
| title_sort | mosaic tp53 mutation on tumour development in pigs a case study |
| url | http://dx.doi.org/10.1155/2023/7000858 |
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