Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatment

Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatment

Abstract Background Elevated serum cholesterol levels are linked to an increased risk of colorectal adenomas and colorectal cancer (CRC), yet the role of serum low-density lipoprotein (LDL) in CRC development remains unclear. This study explores the impact of cholesterol on tumor growth and the pote...

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Bibliographic Details
Main Authors: Xiaoliang Xie, Wenjing Wang, Haiming Zhang, Shaohui Zhao, Na Zhang, Ying Gao, Quanxia Liu, Xiaomei Chen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Low-density lipoprotein
Gut microbiota
Simvastatin
Lactobacillus
Online Access:https://doi.org/10.1186/s12885-025-14379-3
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