Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation?
Introduction. Constipation is a common adverse drug reaction. Objective. Study associations between drugs and constipation in nursing home residents. Design. Cross-sectional study. Material and Methods. Nursing home residents above 60 years of age were included. Demographics, diet, physical activity...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/290231 |
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| author | Gunvor S. Fosnes Stian Lydersen Per G. Farup |
| author_facet | Gunvor S. Fosnes Stian Lydersen Per G. Farup |
| author_sort | Gunvor S. Fosnes |
| collection | DOAJ |
| description | Introduction. Constipation is a common adverse drug reaction. Objective. Study associations between drugs and constipation in nursing home residents. Design. Cross-sectional study. Material and Methods. Nursing home residents above 60 years of age were included. Demographics, diet, physical activity, activity of daily living, nutritional status, use of drugs, and diseases were recorded. Constipation was defined as functional constipation or constipation-predominant IBS according to the Rome III criteria and/or regular use of laxatives. Drugs were classified according to the Anatomical-Therapeutic-Chemical Classification System (ATC), and anticholinergic effect was noted. Results. In all, 79 men and 188 women with a mean age of 85.4 (SD 7.1) years were included. The prevalence of constipation was 71.5%. Use of drugs in general, including polypharmacy, was not associated with constipation. Reduced activity of daily living (OR = 0.71, 95% CI : 0.60–0.84, P<0.001), other antidepressants (N06AX) (OR 3.08, 95% CI : 1.09–8.68, P=0.03), and benzodiazepine derivatives (N05BA) (OR = 2.80, 95% CI : 1.12–7.04, P=0.03) were significantly associated with constipation; drugs with markedly anticholinergic effect (OR = 3.7, 95% CI : 0.78–17.53, P=0.10), natural opium alkaloid (N02AA) (OR = 5.01, 95% CI : 0.95–25.94, P=0.06), and propionic acid derivatives (M01AE) (OR = 7.00, 95% CI : 0.75–65.08, P=0.09) showed a trend. Conclusion. In elderly with constipation, focus should be on specific groups of drugs and nonpharmacological factors, not on drugs in general. |
| format | Article |
| id | doaj-art-ebc2adaa3aa04105a1fb88fe9854b4c2 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ebc2adaa3aa04105a1fb88fe9854b4c22025-02-03T07:26:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/290231290231Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation?Gunvor S. Fosnes0Stian Lydersen1Per G. Farup2Department of Medicine, Innlandet Hospital Trust, 2819 Gjøvik, NorwayUnit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, NorwayUnit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, NorwayIntroduction. Constipation is a common adverse drug reaction. Objective. Study associations between drugs and constipation in nursing home residents. Design. Cross-sectional study. Material and Methods. Nursing home residents above 60 years of age were included. Demographics, diet, physical activity, activity of daily living, nutritional status, use of drugs, and diseases were recorded. Constipation was defined as functional constipation or constipation-predominant IBS according to the Rome III criteria and/or regular use of laxatives. Drugs were classified according to the Anatomical-Therapeutic-Chemical Classification System (ATC), and anticholinergic effect was noted. Results. In all, 79 men and 188 women with a mean age of 85.4 (SD 7.1) years were included. The prevalence of constipation was 71.5%. Use of drugs in general, including polypharmacy, was not associated with constipation. Reduced activity of daily living (OR = 0.71, 95% CI : 0.60–0.84, P<0.001), other antidepressants (N06AX) (OR 3.08, 95% CI : 1.09–8.68, P=0.03), and benzodiazepine derivatives (N05BA) (OR = 2.80, 95% CI : 1.12–7.04, P=0.03) were significantly associated with constipation; drugs with markedly anticholinergic effect (OR = 3.7, 95% CI : 0.78–17.53, P=0.10), natural opium alkaloid (N02AA) (OR = 5.01, 95% CI : 0.95–25.94, P=0.06), and propionic acid derivatives (M01AE) (OR = 7.00, 95% CI : 0.75–65.08, P=0.09) showed a trend. Conclusion. In elderly with constipation, focus should be on specific groups of drugs and nonpharmacological factors, not on drugs in general.http://dx.doi.org/10.1155/2012/290231 |
| spellingShingle | Gunvor S. Fosnes Stian Lydersen Per G. Farup Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? Gastroenterology Research and Practice |
| title | Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? |
| title_full | Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? |
| title_fullStr | Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? |
| title_full_unstemmed | Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? |
| title_short | Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? |
| title_sort | drugs and constipation in elderly in nursing homes what is the relation |
| url | http://dx.doi.org/10.1155/2012/290231 |
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