Congenital Cytomegalovirus in Algiers, Algeria, a Descriptive Case Series Study
Cytomegalovirus (CMV) is an endemic ubiquitous herpes virus transmitted through saliva, urine, genital secretions, mononuclear blood cells, and transplanted tissue. It is a common infection with mild symptoms or asymptomatic in the immunocompetent individuals but can be severe in the immunocompr...
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2022-06-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
| Subjects: | |
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| Summary: | Cytomegalovirus (CMV) is an endemic ubiquitous herpes virus transmitted
through saliva, urine, genital secretions, mononuclear blood cells, and
transplanted tissue. It is a common infection with mild symptoms or
asymptomatic in the immunocompetent individuals but can be severe in the
immunocompromised individuals, e.g., HIV-infected individuals, transplanted
and cancer patients, and fetuses. CMV is the leading cause of congenital viral
infection and the leading non-hereditary cause of sensorineural hearing loss and
mental retardation in early childhood. Here, we describe the clinical and
laboratory monitoring of four congenital CMV (cCMV) cases referred to
Pediatric Belfort Establishment in Algiers in 2019, 2020, and 2021. All the
patients had developed signs and symptoms of postnatal CMV infection with
intrauterine growth retardation. The clinical manifestations differed; some
presented cytopenia with or without hepatosplenomegaly and others a clinical
and biological cholestasis syndrome. All our patients had intrauterine growth
retardation. A CMV PCR of a urine sample was positive. Treatment for six
weeks based on ganciclovir, with a relay by valganciclovir. |
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| ISSN: | 2345-5349 2345-5330 |