Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons

Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons

Age-related cognitive decline is linked to impaired autophagy and hippocampal dysfunction. This study investigates the role of Sirtuin 2 (SIRT2) in age-related cognitive decline, focusing on its impact on autophagy and hippocampal function. Quantitative proteomic analysis revealed 67 significantly d...

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Bibliographic Details
Main Authors: Zhenyuan Zhang, Lan Zhang, Yidan Zhang, Yuan Zhao, Ya Gao, Cong Zhang, Dongxiao Li, Xiangjian Zhang, Guofeng Yang, Jian Zhang
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Brain Research Bulletin
Subjects:
Brain aging
Autophagy
Sirtuin 2 (SIRT2)
Proteomic
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025003132
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