Single-cell RNA sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer

Single-cell RNA sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer

Abstract Muscle-invasive bladder cancer (MIBC) is characterized by a complex tumor microenvironment (TME) that drives aggressive progression and treatment resistance. Previous studies have highlighted the roles of cancer-associated fibroblasts (CAFs) and exhausted T (Tex) cells in MIBC, but their in...

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Main Authors: Zige Liu, Xingning Mao, Yuli Xie, Yunkun Yan, Xiang Wang, Junhao Mi, Hao Yuan, Jiange Zhang, Caisheng Huang, Jianxin Chen, Mujia Jili, Shengzhu Huang, Qingyun Zhang, Fubo Wang, Zengnan Mo, Rirong Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08094-9
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