Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons

Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons

Abstract Bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia share genetic architecture, yet their molecular mechanisms remain elusive. Both common and rare genetic variants contribute to neural dysfunction, impacting cognition and behavior. This study investigates the molecula...

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Main Authors: Karolina Worf, Natalie Matosin, Nathalie Gerstner, Anna S. Fröhlich, Anna C. Koller, Franziska Degenhardt, Holger Thiele, Marcella Rietschel, Madhara Udawela, Elizabeth Scarr, Brian Dean, Fabian J. Theis, Nikola S. Mueller, Janine Knauer-Arloth
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03366-8
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