Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy

Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy

Abstract In the absence of tumor antigen specificity, direct chemokine administration carries the risk of significant “on-target, off-tumor” toxicities, highlighting the need for small-molecule approaches with reduced immunogenicity. This study investigates the synergistic potential of norcantharidi...

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Bibliographic Details
Main Authors: Feng Zhao, Liming Gong, Ping Wang, Dong Chen, Shijie Cao, Feifei Yang, Manqing Tang, Yuanyuan Meng, Yuming Wang, Lin Miao, Yunfei Li, Wei Huang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Chemokine immunotherapy
Small molecule strategy
β-catenin inhibition
Nanoparticle colocalization
Metastasis mitigation
Online Access:https://doi.org/10.1186/s12951-025-03425-8
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