Mycobacteria that cause tuberculosis have retained ancestrally acquired genes for the biosynthesis of chemically diverse terpene nucleosides.

Mycobacteria that cause tuberculosis have retained ancestrally acquired genes for the biosynthesis of chemically diverse terpene nucleosides.

Mycobacterium tuberculosis (Mtb) releases the unusual terpene nucleoside 1-tuberculosinyladenosine (1-TbAd) to block lysosomal function and promote survival in human macrophages. Using conventional approaches, we found that genes Rv3377c and Rv3378c, but not Rv3376, were necessary for 1-TbAd biosynt...

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Main Authors: Jacob A Mayfield, Sahadevan Raman, Alexandrea K Ramnarine, Vivek K Mishra, Annie D Huang, Sandrine Dudoit, Jeffrey Buter, Tan-Yun Cheng, David C Young, Yashodhan M Nair, Isobel G Ouellet, Braden T Griebel, Shuyi Ma, David R Sherman, Ludovic Mallet, Kyu Y Rhee, Adriaan J Minnaard, D Branch Moody
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-09-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002813
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