Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia
Cardiovascular diseases (CVDs) are the leading global cause of mortality and disease burden. Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs. The biochemical mechanism of statins consists of competitive inhibition of the 3-hydroxy-3-methylglutaryl-...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250001 |
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| author | Guillermo Santos-Sánchez Ana Isabel Álvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro |
| author_facet | Guillermo Santos-Sánchez Ana Isabel Álvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro |
| author_sort | Guillermo Santos-Sánchez |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are the leading global cause of mortality and disease burden. Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs. The biochemical mechanism of statins consists of competitive inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme (HMG-CoAR), the limiting enzyme in cholesterol biosynthesis. Due to statin intolerance in some patient groups, the search for new inhibitors is a field of great interest. This review focusses on the studies reporting the inhibitory effect of protein hydrolysates and biopeptides on the HMG-CoAR enzyme activity. The analysis of the action mechanism and physicochemical characteristics of the HMG-CoAR inhibitory peptides revealed that the molecular weight, amino acid composition, charge, and polarity are key aspects of the interaction with the HMG-CoAR enzyme. In conclusion, this review reveals the potential of using food peptides as new cholesterol-lowering agents and opens a new interesting field of research. However, clinical approaches are mandatory to confirm their therapeutic hypercholesterolemic effect. |
| format | Article |
| id | doaj-art-ebafd09a3b88418aa59a82516febaff2 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-ebafd09a3b88418aa59a82516febaff22025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363083309410.26599/FSHW.2023.9250001Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemiaGuillermo Santos-Sánchez0Ana Isabel Álvarez-López1Eduardo Ponce-España2Patricia Judith Lardone3Antonio Carrillo-Vico4Ivan Cruz-Chamorro5Instituto de Biomedicina de Sevilla, Instituto de Biomedicina de Sevilla (IbiS); Hospital Universitario Virgen del Rocío; Consejo Superior de Investigaciones Científicas (CSIC); Universidad de Sevilla, Seville 41013, SpainInstituto de Biomedicina de Sevilla, Instituto de Biomedicina de Sevilla (IbiS); Hospital Universitario Virgen del Rocío; Consejo Superior de Investigaciones Científicas (CSIC); Universidad de Sevilla, Seville 41013, SpainInstituto de Biomedicina de Sevilla, Instituto de Biomedicina de Sevilla (IbiS); Hospital Universitario Virgen del Rocío; Consejo Superior de Investigaciones Científicas (CSIC); Universidad de Sevilla, Seville 41013, SpainInstituto de Biomedicina de Sevilla, Instituto de Biomedicina de Sevilla (IbiS); Hospital Universitario Virgen del Rocío; Consejo Superior de Investigaciones Científicas (CSIC); Universidad de Sevilla, Seville 41013, SpainInstituto de Biomedicina de Sevilla, Instituto de Biomedicina de Sevilla (IbiS); Hospital Universitario Virgen del Rocío; Consejo Superior de Investigaciones Científicas (CSIC); Universidad de Sevilla, Seville 41013, SpainInstituto de Biomedicina de Sevilla, Instituto de Biomedicina de Sevilla (IbiS); Hospital Universitario Virgen del Rocío; Consejo Superior de Investigaciones Científicas (CSIC); Universidad de Sevilla, Seville 41013, SpainCardiovascular diseases (CVDs) are the leading global cause of mortality and disease burden. Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs. The biochemical mechanism of statins consists of competitive inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme (HMG-CoAR), the limiting enzyme in cholesterol biosynthesis. Due to statin intolerance in some patient groups, the search for new inhibitors is a field of great interest. This review focusses on the studies reporting the inhibitory effect of protein hydrolysates and biopeptides on the HMG-CoAR enzyme activity. The analysis of the action mechanism and physicochemical characteristics of the HMG-CoAR inhibitory peptides revealed that the molecular weight, amino acid composition, charge, and polarity are key aspects of the interaction with the HMG-CoAR enzyme. In conclusion, this review reveals the potential of using food peptides as new cholesterol-lowering agents and opens a new interesting field of research. However, clinical approaches are mandatory to confirm their therapeutic hypercholesterolemic effect.https://www.sciopen.com/article/10.26599/FSHW.2023.9250001functional foodscholesterolcardiovascular diseasesstatins3-hydroxy-3-methylglutaryl-coenzyme a |
| spellingShingle | Guillermo Santos-Sánchez Ana Isabel Álvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia Food Science and Human Wellness functional foods cholesterol cardiovascular diseases statins 3-hydroxy-3-methylglutaryl-coenzyme a |
| title | Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia |
| title_full | Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia |
| title_fullStr | Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia |
| title_full_unstemmed | Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia |
| title_short | Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia |
| title_sort | food derived peptides with inhibitory capacity for hmg coa reductase activity a potential nutraceutical for hypercholesterolemia |
| topic | functional foods cholesterol cardiovascular diseases statins 3-hydroxy-3-methylglutaryl-coenzyme a |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250001 |
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