Precision neuroregulation combining liquid metal and magnetic stimulation
Abstract Background Electromagnetic field-based neuroregulation technology is a crucial technique for treating central nervous system and peripheral nervous system disorders. However, the use of invasive electrodes has unavoidable problems such as the risk of inflammation due to high hardness, elect...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of NeuroEngineering and Rehabilitation |
| Online Access: | https://doi.org/10.1186/s12984-025-01575-2 |
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| author | Yuheng Wang Junjie Lin Kai Zhu Yuhui Nie Mengyuan Wang Xiaoxu Ma Xu Liu Ruru Wang Wenshu Mai Fangxuan Chu Ruixu Liu Jiankang Wu Jingna Jin Xiaoqing Zhou Ren Ma Xin Wang Tao Yin Zhipeng Liu Shunqi Zhang |
| author_facet | Yuheng Wang Junjie Lin Kai Zhu Yuhui Nie Mengyuan Wang Xiaoxu Ma Xu Liu Ruru Wang Wenshu Mai Fangxuan Chu Ruixu Liu Jiankang Wu Jingna Jin Xiaoqing Zhou Ren Ma Xin Wang Tao Yin Zhipeng Liu Shunqi Zhang |
| author_sort | Yuheng Wang |
| collection | DOAJ |
| description | Abstract Background Electromagnetic field-based neuroregulation technology is a crucial technique for treating central nervous system and peripheral nervous system disorders. However, the use of invasive electrodes has unavoidable problems such as the risk of inflammation due to high hardness, electrical connections and the need for batteries. On the other hand, non-invasive magnetic stimulation has limitations such as centimeter-level focal areas and shallow stimulation depth. Methods To enhance the precision and effectiveness of wireless magnetic stimulation, we employed a figure-8 magnetic stimulation coil (8-coil) to generate a magnetic field, combined with an injectable, highly conductive, and flexible liquid metal (LM) to produce a millimeter-scale focused electric field. A coaxial electric field measurement electrode was used to establish an agar phantom-based electric field measurement platform. The sciatic nerve of C57 mice was stimulated under acute anesthesia conditions, and electromyography (EMG) signals were collected to evaluate the enhancement of stimulation effects. Long-term safety was assessed through four weeks of implantation. Results Theoretical analysis and finite element simulations demonstrated that the combination of LM and the 8-coil generated a millimeter-scale enhanced vector electric field within the tissue. Measured electric field distributions closely aligned with theoretical and simulation results. In the sciatic nerve experiments on mice, 1 µL of LM under a 0.45 T magnetic field significantly increased EMG signals and leg movement amplitude by approximately 500%. Long-term implantation under magnetic stimulation revealed no adverse effects. Conclusions This method utilizes focused electric fields to improve the precision and effectiveness of neuro-magnetic stimulation. It holds promise as a novel approach for precise stimulation. Preliminary evidence was provided for the safety of in vivo LM implantation under external magnetic fields. |
| format | Article |
| id | doaj-art-ebac5f59034d449c8f5b5dbe49d051bf |
| institution | OA Journals |
| issn | 1743-0003 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of NeuroEngineering and Rehabilitation |
| spelling | doaj-art-ebac5f59034d449c8f5b5dbe49d051bf2025-08-20T02:16:06ZengBMCJournal of NeuroEngineering and Rehabilitation1743-00032025-04-0122111210.1186/s12984-025-01575-2Precision neuroregulation combining liquid metal and magnetic stimulationYuheng Wang0Junjie Lin1Kai Zhu2Yuhui Nie3Mengyuan Wang4Xiaoxu Ma5Xu Liu6Ruru Wang7Wenshu Mai8Fangxuan Chu9Ruixu Liu10Jiankang Wu11Jingna Jin12Xiaoqing Zhou13Ren Ma14Xin Wang15Tao Yin16Zhipeng Liu17Shunqi Zhang18Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical CollegeAbstract Background Electromagnetic field-based neuroregulation technology is a crucial technique for treating central nervous system and peripheral nervous system disorders. However, the use of invasive electrodes has unavoidable problems such as the risk of inflammation due to high hardness, electrical connections and the need for batteries. On the other hand, non-invasive magnetic stimulation has limitations such as centimeter-level focal areas and shallow stimulation depth. Methods To enhance the precision and effectiveness of wireless magnetic stimulation, we employed a figure-8 magnetic stimulation coil (8-coil) to generate a magnetic field, combined with an injectable, highly conductive, and flexible liquid metal (LM) to produce a millimeter-scale focused electric field. A coaxial electric field measurement electrode was used to establish an agar phantom-based electric field measurement platform. The sciatic nerve of C57 mice was stimulated under acute anesthesia conditions, and electromyography (EMG) signals were collected to evaluate the enhancement of stimulation effects. Long-term safety was assessed through four weeks of implantation. Results Theoretical analysis and finite element simulations demonstrated that the combination of LM and the 8-coil generated a millimeter-scale enhanced vector electric field within the tissue. Measured electric field distributions closely aligned with theoretical and simulation results. In the sciatic nerve experiments on mice, 1 µL of LM under a 0.45 T magnetic field significantly increased EMG signals and leg movement amplitude by approximately 500%. Long-term implantation under magnetic stimulation revealed no adverse effects. Conclusions This method utilizes focused electric fields to improve the precision and effectiveness of neuro-magnetic stimulation. It holds promise as a novel approach for precise stimulation. Preliminary evidence was provided for the safety of in vivo LM implantation under external magnetic fields.https://doi.org/10.1186/s12984-025-01575-2 |
| spellingShingle | Yuheng Wang Junjie Lin Kai Zhu Yuhui Nie Mengyuan Wang Xiaoxu Ma Xu Liu Ruru Wang Wenshu Mai Fangxuan Chu Ruixu Liu Jiankang Wu Jingna Jin Xiaoqing Zhou Ren Ma Xin Wang Tao Yin Zhipeng Liu Shunqi Zhang Precision neuroregulation combining liquid metal and magnetic stimulation Journal of NeuroEngineering and Rehabilitation |
| title | Precision neuroregulation combining liquid metal and magnetic stimulation |
| title_full | Precision neuroregulation combining liquid metal and magnetic stimulation |
| title_fullStr | Precision neuroregulation combining liquid metal and magnetic stimulation |
| title_full_unstemmed | Precision neuroregulation combining liquid metal and magnetic stimulation |
| title_short | Precision neuroregulation combining liquid metal and magnetic stimulation |
| title_sort | precision neuroregulation combining liquid metal and magnetic stimulation |
| url | https://doi.org/10.1186/s12984-025-01575-2 |
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